Factor Deficient Plasmas

Hemostasis Reagents

HORIBA Medical offers a full range of immunodepleted factor deficient plasmas covering the two pathways of the coagulation cascade. They contain <1% residual factor activity of the given coagulation factor, while the levels of the other coagulation factors are normal.

Extrinsic and common pathway (Factor II, V, VII, X)

Deficient plasmas used for quantitative determination of factor II, V, VII, X with prothrombin time (PT) thromboplastin time reagent and one-stage coagulation test in decalcified plasmas. The decreased level of factors in common and extrinsic pathway could be observed in the following cases:
• Congenital or acquired factor deficiency states
• During treatment with anticoagulants
• In case of vitamin K deficiency (reduced intake or metabolic disorder)
• Liver disease (cirrhosis, hepatitis)
• During factor “depletion” due to disseminated intravascular coagulopathy (DIC).

Intrinsic pathway (Factor VIII, IX, XI, XII)

Deficient plasmas used for quantitative determination of factor VIII, IX, XI, XII with activated partial thromboplastin time (APTT) reagent and one-stage coagulation test in decalcified plasmas. The decreased level of factors in common and intrinsic pathway could be observed in the following cases:
• Congenital or acquired factor deficiency states (Hemophilia A: factor VIII deficiency, Hemophilia B: factor IX deficiency)
• Liver disease
• Autoimmune hemophilia states

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