Particle Size Reduction

Many particle size measurements are made to track size reduction operations such as milling, mixing, homogenizing, etc. The size reduction unit operation is performed under set conditions or for a required time frame until a specified size is achieved, as determined by the measurement. The choice of particle size analysis technique can be based on the size distribution of the input, output, or both. Laser diffraction is the most common analysis technique for monitoring size reduction operations due to its very broad dynamic range. The LA-960 Particle Size Analyzer is uniquely capable of measuring from several millimeters down to the nanometer scale, making it the instrument of choice for many size reduction operations.

Microfluidizers®

One method for particle size reduction is the use of Microfluidizers® which expose the material to consistent shear levels using a unique fixed-geometry interaction chamber (see www.microfluidicscorp.com).

As depicted above, product is input into a reservoir which supports high solid content. A high pressure pump generates forces up to 40,000 psi (2578 bar) in order to force the product stream into precisely engineered microchannels within the unique interaction chamber. Because of the ability to control shear rates, the smallest pressure required is typically used. Once inside the chamber, product is exposed to consistent and intense impact and shear forces and then is immediately cooled. This repeatable process results in tiny particles with a uniform distribution.

Applications: Size reduction of API

One common use of a Microfluidizer® is particle size reduction of an active pharmaceutical ingredient (API). The images below show the particle size of the API before and after processing in the Microfluidizer®.  The particle size analysis was performed using a HORIBA LA-910 laser diffraction analyzer.  

Before processing
After processing: d50=385 nm

Application: Size reduction of emulsions (ophthalmic solution)

This technology is also commonly used to reduce the droplet size distribution of emulsions. The images below show the particle size of an emulsion used as an ophthalmic solution before and after processing. The particle size analysis was performed using a HORIBA LA-910 laser diffraction analyzer.

Before processing
After processing: d50=96nm

Download the Application Note on Monitoring Particle Size Reduction of Pharmaceutical Products. (You need to be logged in).

Laser diffraction analyzers by HORIBA are often the best choice of instruments to track size reduction operations, in particular when the processed material may be below 100nm.

Particle Analyzers for Size Reduction Applications

LA-960

The LA-960 uses Mie Scattering (laser diffraction) to measure particle size of suspensions or dry powders. The speed and ease-of-use of this technique makes it the popular choice for most applications.

LA 300

The LA-300 uses Mie Scattering (laser diffraction) to measure particle size of suspensions. The speed and ease-of-use of this technique makes it the most popular for many applications.

CAMSIZER Dynamic Image Analyzer

HORIBA's CAMSIZER features dynamic image analysis to provide rapid and precise particle size and particle shape distributions for dry powders and bulk material in the size range from 20µm to 30mm.

CAMSIZER XT Dynamic Image Analyzer

HORIBA's CAMSIZER XT features dynamic image analysis to provide rapid and precise particle size and particle shape distributions for dry powders and wet dispersions in the size range from 1µm to 3mm.