Can Raman be used for in vivo analysis?

Yes.  Raman is a non-destructive, non-contact chemical analysis technique, which can be applied to in vivo analysis.  Typically this done using a compact remote Raman probe, which is coupled to the spectrometer and laser using flexible fibre optic cables.

There are many examples of in vivo analysis, particularly in the analysis of cosmetic and topical medicines on the skin.  Current research is looking at the application of in vivo Raman spectroscopy in surgical environments, where it can be used as an immediate indication of tissue health.

Example of in vivo Raman analysis of cosmetic formulations on skin
Example of in vivo Raman analysis of cosmetic formulations on skin
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