Professor Bin Ren is now a professor in Chemistry and vice director of the state key Lab of physical chemistry of solid surfaces, Xiamen University.

He obtained his bachelor and Ph. D in the Department of Chemistry, Xiamen University. He was an Alexander von Humboldt fellow and worked in Fritz-Haber Institute, Germany on tip-enhanced Raman spectroscopy.

He was awarded the distinguished young scholar fund of the national natural science foundation of China.

He has published over 200 papers in English and has an H-index of 45. He is now an Editor of Spectrochimica Acta A.

His research field is on surface-enhanced Raman spectroscopy, tip-enhanced Raman spectroscopy and electrochemistry, and their application in studying the fundamental aspect of surface and interfaces of energy and bio-related systems.

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Surface-enhanced Raman spectroscopy for detection of biomolecules and the nanoenvironment

Surface-enhanced Raman spectroscopy (SERS) is particularly powerful for biological study because it can obtain the fingerprint information of the system we are interested in under the aqueous and ambient conditions, but with a much higher sensitivity compared with normal Raman spectroscopy. To obtain SERS signal of biomolecules with good reproducibility and high sensitivity is extremely important for a wide application of SERS in biological systems and is also a great challenge for SERS. molecules with metal colloids of high concentration and the detection is performed during the drying process, and the maximum sensitivity can be achieved right before the complete drying of the colloidal solution. This technique allows the SERS detection of 20 common amino acids and some important peptides with a highly reproducible signal. The second method is to modify the surface of SERS-active nanoparticles or solid SERS substrates with some halide ions. The method was successfully used for direct detection of proteins and DNAs. In the DNA case, the signal of phosphate backbone was used as internal standard, so that the absolute contribution of the each base can be quantitatively determined, which provides an effective way for the identification of DNA with single base sensitivity, and the hybridization event of DNA can be clearly identified. For the protein case, the SERS signal of protein was enhanced by at least 1000 time over the solution species, while but showing almost identical feature to that of the solution signal of proteins. This method allows the quantitative analysis of proteins and mixture of proteins. We will also discuss some part of work related to real time imaging of the living cells by directly using the fingerprint information of the biomolecules themselves and indirectly using Raman labels for the microenvironmental pH imaging of live cells.