HORIBA to Launch the nanoPartica SZ-100V2 Series Nanoparticle Analyzer

September 13, 2018

Measurement Sensitivity Approximately 15 Times Higher than the Current Model

HORIBA, a global leader in particle characterization instrumentation and solutions, has announced the release of the nanoPartica SZ-100V2 series nanoparticle analyzer, which measures quantity, size, and surface charge of nanoparticles.
This state-of-the-art nanoparticle analyzer performs accurate and stable measurement of low-concentration samples, which are often used at research centers of cutting-edge technology, and particles with a low scattered light intensity, which have been hard to measure until now. This functionality will subsequently meet a broad spectrum of measurement needs ranging from technical development in nanomaterial and biotechnology fields to production of ceramics and metals.
Through the combined utility of a high-powered laser (100 mW) and an improved layout of the optical system, the measurement range has expanded (0.3nm to 10,000nm) and measurement sensitivity has increased by approximately 15 times compared with the current model. Furthermore, a greater flexibility in customization by the wavelength of laser sources and optional accessories increases efficiency in R&D and quality control as well as supports research projects that require high resolutions in a variety of fields.

About Nanoparticle Analyzers

The size and uniformity of particles of raw materials used for advanced research and production processes can significantly affect product functions and characteristics. The nanoparticle analyzer is used for R&D and quality control of various products, including electrolytes, which are used to make rechargeable batteries; nano materials, such as carbon nano tubes, whose size are 1/50,000 of human hair; antibody drugs; ceramics; and pigments.

The market for whole-particle-number measurement is estimated to be worth JPY74.5 billion globally in 2018 and is expected to expand at a CAGR of 3.4% up until 2020. (Survey by HORIBA)

nanoPartica SZ-100V2 Series Nanoparticle Analyzer

Main Features

With a conventional laser, it has been hard to analyze small particles with weak scattered light signals, which are required for analyzing nanoparticles, diluted samples, and samples that are difficult to be condensed due to difficulty in gaining stable scattered light. Equipped with a high-power laser (100 mW), the nanoPartica SZ-100V2 series gains a greater amount of scattered light and successfully reduces noise by improving the layout of the optical system, with the result that measurement sensitivity has increased by approximately 15 times compared with the current model.

  1. Achieves simple and clear analysis of multiple elements of single nanoparticles. Simultaneously analyzes three parameters of “particle size, zeta potential, and molecular weight” with high sensitivity and in a broad range.

  2. Measurement sensitivity approximately 15 times higher than HORIBA’s current model.
    Adoption of a high-power laser source and an original layout of the optical system for reducing noise make it possible to measure both high and low concentration samples.

  3. Ranges for particle diameter measurement (0.3nm - 10,000nm) and zeta charge (-500 mV - +500 mV) have improved.

  4. Users can customize the instrument according to their specific needs by fluorescence photoablation or by changing the wavelength of light sources and output intensity. For example, in a model where gel for artificial cartilage or 3D printers is to be evaluated, the gel networks can be easily analyzed due to the introduction of a mechanism for measuring multi-points in gel as well as an operation procedure focused on gel.

Measurement Fields and Applications

  • Food and beverages: Controlling flavor, sensation on the palate, best-before dates, etc.
  • Semiconductor materials: Production control of semiconductor wafer abrasives
  • Pharmaceuticals and cosmetics: R&D and quality control of preparation, pulverization, coating, etc.
  • Precision equipment: Development of materials such as inks for high-speed, high-quality printing
  • Chemical industry: R&D and quality control of preparation, granulation, pulverization, coating, etc.
  • Gel materials: R&D and quality control of materials for artificial cartilage, 3D printers, etc.
  • Ceramics: R&D and shipment/receiving inspection of fine ceramics powder materials
  • Catalysts and rechargeable batteries: Research, development, improvement, and quality control of new materials
  • Bio-life science: R&D of antivirus, antibody drugs, etc.
  • Agriculture and forestry, water, and home electronics: Fine bubbles with bactericidal and purifying effect

Key Specifications

(D x W x H)

385 mm x 528 mm x 273 mm (excluding protrusions)


Approx. 25 kg


Particle diameter, zeta potential, and molecular weight*1

Particle diameter measurement principle

Photon correlation method

Particle diameter measurement range

0.3 nm – 10,000 nm

Particle diameter measurement accuracy

± 2% (variances in standard particles not considered) (in compliance with ISO22412:2008 and JIS Z8826:2005)

Zeta potential measurement principle

Electrophoretic laser Doppler method*2

*1 Molecular weight measurement: Molecular weight is measured to determine how many molecules there are when, for example, producing animal-derived, low-cost synthetic hyaluronic acids used in cosmetics. This technique is used for broad applications from R&D to quality control in such fields as biotechnology and synthetic materials.

*2 Electrophoretic laser Doppler method: A method for measuring the electrical induction of particles by the difference in frequencies between a laser that has irradiated a sample and a laser that has not irradiated a sample. Zeta potential is determined by using the regularity that, the more cohesive particles are, the more slowly they are electrically induced.


About Particle Diameter Measurement
The diameter of nanoparticles is measured by irradiating solutions with a laser and detecting light emitted by particles. By detecting changes in intensity of light thus emitted, the rate of movement of particles can be measured by an operational unit. Because the rate of movement is correlated with the size of particles, the particle size is determined by an operation procedure based on a proprietary theory.

About Zeta Potential Measurement
To measure zeta potential, which shows the cohesiveness of nanoparticles, the rate of movement of particles in a solution to which voltage is applied is measured. To begin with, apply voltage to a solution with two electrode plates in it. Positively charged particles in the solution move toward the negative electrode and negatively charged particles move toward the positive electrode (electrophoresis). If irradiated with a laser, light with different frequencies is emitted from particles in electrophoresis. In other words, a difference in frequencies can be observed compared with a laser with which a solution is not irradiated (electrophoretic laser Doppler method). The difference is then used to calculate the rate of movement of the particles, which is converted into zeta potential.

Categories: Press release