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HORIBA Chase the Case #51 - Chronic Myeloid Leukemia
Clinical case of Chronic Myeloid Leukemia (CML): See how HORIBA Yumizen analyzers detect blasts, basophilia, and immature granulocytes for early diagnosis.
Chase the Case #51 - Chronic Myeloid Leukemia
Yumizen H500 Hematology Analyzer
December 2025 (PDF for print)
Patient Demographics: Male, 48 years old
Symptoms: Weakness, abdominalpain
Diagnosis: Chronic Myeloid Leukemia (CML) – Chronic Phase
Microscopic Review: Blasts: 2%, Lymphocytes: 10%, Monocytes: 1%, Neutrophils: 49%, Eosinophils: 3%, Basophils: 6%, Promyelocytes: 2%, Myelocytes: 18%, Metamyelocytes: 9%, Nucleated RBCs: 2 per 100 WBCs observed
Other Tests: BCR-ABL t(9;22) Philadelphia Chromosome: Positive
How Yumizen H500 Assisted: On the DIFF scattergram, we observed an immature granulocytic population, which was also reflected in the extended WBC differential (high IMG and LIC). The scattergram further revealed a compact blast population located between the lymphocyte, atypical lymphocyte, and monocyte areas. These small to moderately sized blasts were situated in the ALY region and exhibited basophilic cytoplasm with irregular nuclear contours, containing two to three nucleoli. The suspected pathology alarms also indicated basophilia, which was confirmed on the blood smear. Additionally, the Yumizen H500 analyzer generated alarms for abnormal differentiation, high IMG, high LIC, and the presence of blasts, all of which suggested the need to investigate for hematologic malignancy.
Blood smear showed left-shifted neutrophilia with all stages of immaturity present, from blasts (2%) to mature neutrophils. Basophils were increased; and 2 n RBCs, including a polychromatic erythroblast.
This clinical case has been provided by Specialized Hematology Diagnostic Lab, Mumbai, India.
