Igor K. Lednev is a professor at the University at Albany, State University of New York.  He graduated from Moscow Institute of Physics and Technology, Russian Federation, receiving his Ph.D. degree in 1983. Then Dr. Lednev worked at the Institute of Chemical Physics, Russian Academy of Sciences, as a group leader.  As an academic visitor, he worked in several leading laboratories around the world including the United Kingdom, Japan, Canada and Germany. In 1997, Dr. Lednev came to the US and joined Prof. Sanford Asher laboratory at the University of Pittsburgh until he moved to the University at Albany in 2002. Dr. Lednev research is focused on the development and application of novel laser spectroscopy for biomedical research and forensic purposes.  Dr. Lednev served as an advisory member for the White House Subcommittee on Forensic Science.  He is a member of the International Steering Committee of the International Conference on Raman Spectroscopy and serves on editorial boards of four scientific journals including Journal of Raman Spectroscopy and Biochimica et Biophysica Acta.  Dr. Lednev is a fellow of the Society for Applied Spectroscopy.  He received the Research Innovation Award and the University President Award for Excellence in Research.  He has co-authored over 160 publications in peer-reviewed journals, including 2009 article in Forensics Science International, which is one of the most downloaded and most cited papers from this top journal in the field. His 2014 article in Biophysical Journal is one of the most read.

Raman Microspectroscopy for Medical Diagnostics and Forensic Purposes

Raman microspectroscopy combined with advanced statistics is uniquely suitable for characterizing microheterogeneous samples.  Understanding the structure and (bio)chemical composition of samples at the microscopic level is important for many practical applications including material science, pharmaceutical industry, etc.  We have recently demonstrated a great potential of Raman microspectroscopy for disease diagnostics and forensic purposes.  In this presentation, we will discuss the development of a new, noninvasive method for Alzheimer’s disease (AD) diagnostics based on Raman microspectroscopy of blood. Near infrared (NIR) Raman microspectroscopy coupled with advanced multivariate statistics was utilized for differentiating patients diagnosed with Alzheimer’s disease, other types of dementia and healthy control subjects with more than 95% sensitivity and specificity. When fully developed, this fast, inexpensive noninvasive method could be used for screening at risk patient populations for AD development and progression.
Raman spectroscopy has already found numerous applications in forensic chemistry providing confirmatory identification of analytes.  The technique is non-destructive, rapid and requires little or no sample preparation.  Furthermore, portable Raman instruments are readily available allowing for crime scene accessibility.  We have recently demonstrated that Raman microspectroscopy can be used for the identification of biological stains at a crime scene indicating the type of body fluid. In addition, peripheral and menstrual blood as well as human and animal blood can be differentiated. We will also discuss the application of Raman spectroscopy for detection and characterization of gunshot residue (GSR).