College of Pharmaceutical Science/ College of Chemistry and Chemical Engineering,Southwest University

Dr. Huang is a Professor of analytical chemistry and pharmaceutical analysis in Southwest University, Chongqing, China.

He graduated from Southwest Normal University in 1986 with a Bachelor degree. After working there for 4 years, he pursued his Mater degree of Analytical Chemistry in Beijing Normal University, and PhD degree of Analytical Chemistry in Peking University for. During 1998.11-1999.10, he worked as a visiting researcher at the department of Analysis and Biochemistry, Central Research Laboratory, Hitachi, Ltd. (Japan). In 2000, he worked in Dr. Johne Liu in group in University of Ottawa as a short-term postdoctoral fellowship. After that, he worked in Professor Imai group in University of Tokyo for two years as a postdoctoral fellowship, engaging the synthesis of fluorescence organic reagents for analytical biochemistry.

With the support of a series of funds such as the National Science Fund for Distinguished Young Scholars, he engaged in the researches of plasmon analytical chemistry, include the bioassembly, nano analytical chemistry, and optical analytical chemistry. He has published more than 330 papers in ACS Nano, Small, Anal Chem, Chem Commun., et al, which have been cited about 5800 times with the H-index of 40.



Optical Property and Analytical Applications of Carbon Dots

Since their first discovery in 2004, fluorescent carbon dots (CDs) have found to be physicochemically and photochemically stable without photobleaching, making them become a star family in biosensing and bioimaging fields.More interestingly, some colorful CDs have been prepared with the same carbon source, which are similar to the optical properties of quantum dots. However, bare CDs are usually weakly fluorescent and hard to attach functional groups on the surface.Regardless continuous efforts in circumventing the problems,challenges still remain to engineer CDs with desirable biosensing and labeling properties, such as high quantum yield, preferable selectivity, for long-term and real-time monitoring of targets of interest.

Our group focuses on the optical property and application of carbon dots. It has been found that CDs presented the excitation wavelength-dependent or independent emission. To improve the quantum yield of carbon dots, carbon dots were doped with nitrogen and germanium which have been applied to biochemical analysis and bioimaging, such as phosphate,tetracycline,mercury (II).For example, a simple method for phosphate (Pi) detection was established by developing an off-on fluorescence probe of europium-adjusted CDs, which has been successfully applied to the detection of Pi in very complicated matrixes such as artificial wetlands system. This work has been highly cited and greatly appreciated.

  • Xu, X.; Ray, R.; Gu, Y.; Ploehn, H. J.; Gearheart, L.; Raker, K.; Scrivens, W. A. J. Am. Chem. Soc. 2004, 126, 12736-12737.
  • Wu, Z. L.; Gao, M. X.; Wang, T. T.; Wan, X. Y.; Zheng, L. L.; Huang, C. Z. Nanoscale 2014, 6, 3868-3874.
  • Wu, Z. L.; Zhang, P.; Gao, M. X.; Liu, C. F.; Wang, W.; Leng, F.; Huang, C. Z. J. Mater. Chem. B 2013, 1, 2868-2873.
  • Wei, W.; Xu, C.; Wu, L.; Wang, J.; Ren, J.; Qu, X. Sci. Rep. 2014, 4, 3564.
  • Ding, C.; Zhu, A.; Tian, Y. Acc. Chem. Res. 2014, 47, 20-30.
  • Trachtenberg, J. T.; Chen, B. E.; Knott, G. W.; Feng, G.; Sanes, J. R.; Welker, E.; Svoboda, K. Nature 2002, 420, 788-794.
  • Yuan, Y. H.; Li, R.; Wang, Q.; Wu, Z. L.; Wang, J.; Liu, H.; Huang, C. Z. Nanoscale 2015, 7, 16841-16847.
  • Zhao, H. X.; Liu, L. Q.; Liu, Z. D.; Wang, Y.; Zhao, X. J.; Huang, C. Z. Chem. Commun. 2011, 47, 2604-2606.
  • Lin, M.; Zou, H. Y.; Yang, T.; Liu, Z. X.; Liu, H.; Huang, C. Z. Nanoscale 2016, 7, DOI:10.1039/c1035nr08177g.