Department of Physiology and Pharmacology,Bone and Joint Initiative,Western University, London, Ontario, Canada

Sims received his BSc in Zoology (University of Western Ontario, 1975) and PhD in Neuroscience (McMaster University, 1982).  Postdoctoral training was carried out in Physiology at The University of Massachusetts Medical School (Worcester Massachusetts) and at Brigham and Women’s Hospital (Harvard Medical School, Boston).

Sims joined Western in 1987, supported by a Medical Research Council Scholarship followed by a Scientist award.  His research focuses on ion channels and calcium in muscle and bone cells.  He has held support from several agencies, including Canadian Institutes of Health Research and The Arthritis Society. Sims served the academic community as Interim Chair of Physiology, Associate Vice-Provost in the School of Graduate and Postdoctoral Studies, and as a member of the Board of Governors.

Sims is chair of the CIHR New Investigator personnel committee, and is past president of the Canadian Physiological Society. He has served on review committees for CIHR, the Alberta Heritage Foundation for Medical Research, the Canadian Arthritis Network and the Arthritis Society.  He has mentored 17 graduate students, 18 postdoctoral fellows, more than 50 undergraduate research trainees and 13 visiting scientists.  His trainees have won national and international awards for their research, and have progressed to independent careers in academia, education, medicine, dentistry and financial markets.  Sims and colleagues pioneered the use of patch clamp and fluorescence methods to study mammalian osteoclasts.  They were the first to identify and characterize ion channels in osteoclasts, and their regulation. Osteoclasts are the therapy target in diseases like rheumatoid arthritis, osteoporosis and metastatic tumors in bone.



Live-cell fluorescence imaging of bone cells