Top 10 Practices for DLS Sizing

  1. Filtering diluents so that the suspending liquid has no “extra” particles.
  2. Ensuring that long-range electrostatic interactions are not affecting your results.
  3. Ensuring that particle-particle collisions are not affecting your results.
  4. Covering your samples so no dust falls in from the air.
  5. Confirming that the autocorrelation function is smooth before examining size results.
  6. Confirming repeatability of Z-average size before examining size distributions.
  7. Ensuring your glassware is clean and dust-free.
  8. Ensuring that the sample has reached thermal equilibrium with the sample chamber in the instrument so that the correct viscosity is used for size calculations.
  9. Ensure that your sample size distribution doesn’t have a tail with particles over 10 microns in diameter.
  10. Filtering suspensions of very small particles (diameter < 50 nm).

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SZ-100 Nanopartica Series Instruments