Can Raman be used for automated assays and high throughput screening?

Since Raman spectroscopy is a non-contact, non-destructive technique, it can be used effectively for automated high throughput screening (HTS) and assay measurements.  Typical applications include analysis of liquids/powders in multiwell plates, crystal screening, and tablet content/uniformity assays with Transmission Raman.

HTS Raman systems use a combination of automated sample movement, autofocus devices, and automated data acquisition and analysis procedures to acquire spectra from hundreds of samples sequentially. HTS screening and automated measurements can even be integrated with full robot handling, removing the need for expertise and operator intervention.

Applications such as diamond like carbon (DLC) coatings for computer hard discs, and crystal and polymorph analysis in drug development now use Raman spectroscopy for automated screening, as well as many other applications which simply require routine analysis of large numbers of samples.

  • LapSpec 6.5 Software
  • Raman Well Plate
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