What is a combined / hybrid / hyphenated Raman system?

A combined / hybrid / hyphenated Raman system couples Raman analysis with another analytical technique – examples include Raman-FTIR, Raman-AFM, Raman-PL and Raman-Epifluorescence.  Hyphenated systems allow more complete sample analysis on a single bench top system, and offer lower cost of ownership compared with two individual systems.  They also remove the need for time consuming alignment of a sample on separate systems to allow the same area to be analysed with complementary techniques.

A range of combined Raman solutions exist, offering different capabilities to the user.

Combining Raman analysis with photoluminescence (PL) detection makes it possible to characterise both the vibrational and electronic properties of materials on a single bench top platform.  Typical applications include analysis of semiconductor and nano-materials for band gap determination, impurity levels and defect detection, recombination mechanisms and material quality.

For more information on Raman-PL please click here

Combining Raman analysis with an atomic force microscope (AFM) can provide physical sample information on the nanometer scale, including topography, hardness, adhesion, friction, surface potential, electrical and thermal conductivity, temperature and piezo response (among many others), together with the chemical information obtained from Raman spectroscopy and imaging.  The end result is a more comprehensive sample characterisation.

For more information on Raman-AFM and TERS please click here

Epifluorescence imaging is widely used within biological fields for visualisation of cell/tissue materials, but does not offer the detailed molecular information that Raman can provide. Combining the two techniques on a single microscope system allows fast location of regions of interest within biological samples and targeted chemical analysis.  Experiments such as FISH (fluorescence in situ hybridisation) are routinely possible on such systems, allowing them to be combined with Raman chemical analysis.

For more information on Raman-Epifluorescence please click here

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