With the rise of protein production using mammalian cell culture, it has become increasingly important to control the quality of the cell culture media for use in production processes. Cell culture media are usually prepared as aqueous solutions and should provide everything a cell line needs for optimal cell growth as well as product yield and quality. This could include amino acids, glucose, vitamins and various other nutrients. The exact composition and concentrations of the components found in a given type of cell culture medium tend to vary depending on the unique needs of a given cell line and are usually considered proprietary information by the manufacturers of said media. In any given bioreactor process it is important to identify the proper type of cell culture medium and its quality because even subtle variations in composition could have a noticeable impact on the growth rate of the cell culture and its yield. Therefore, the composition and quality of cell culture media in bioreactors must be tightly controlled in order to maintain an optimal bioreactor process. As a result, methods of identifying and analyzing the quality of cell culture media have become an important focus in this field.
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