Drug Discovery and Development

HORIBA supports the discovery and development of drug products by pharmaceutical industries, which require an extraordinary amount of time and effort to get to the final delivery to customers. During its entire lifecycle, the quality of the pharmaceuticals is one of the most critical steps, as it continually faces challenges from government and regulatory agencies to ensure quality and efficacy. From drug discovery to post-marketed products, HORIBA provides fast and innovative characterization solutions for all the scientific fields involved.

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Polymorphisms characterization: when Raman microscopy supports the pharmaceutical industry
Polymorphisms characterization: when Raman microscopy supports the pharmaceutical industry
Polymorphisms characterization of active molecules is one piece of important information for the pharmaceutical industry, not only on raw powders, but also in the final form. Raman microscopy remains the most appropriate solution for this application. In this paper, we present an example of polymorphisms characterization by Raman microscopy using the super low frequency module.
Studying heart disease by simultaneous measurement of changes of Sarcomere Length
Studying heart disease by simultaneous measurement of changes of Sarcomere Length
Studying heart disease by simultaneous measurement of changes of Sarcomere Length and concomitant intracellular ionic calcium concentration in freshly isolated cardiac myocytes.
Morphological and chemical characterization of pharmaceutical formulations
Application note: Morphological and chemical characterization of pharmaceutical formulations
In order to control formulations of pharmaceutical products, characterizing their active compounds is critical, especially in terms of morphological and chemical characterization of particles. In this application note, two formulations from a generic and an innovator nasal spray have been analyzed to compare their compounds size and shape, and chemically characterized to compare the two formulations based on the ParticleFinderTM app for LabSpec 6. A focus is done on the active compound.
Raman Hyperspectral Imaging: An essential tool in the pharmaceutical field
Resulting from the combination of Raman spectroscopy and optical microscopy, Raman hyperspectral imaging has proven to be an indispensable tool in the pharmaceutical field. This article will broach a number of Raman hyperspectral imaging applications that were developed in our laboratory, in order to demonstrate the significance of the technique.
Validation of the activity of G-protein-coupled receptors (GPCRs) using SPRi
The Detection of a Low Molecular Weight Enzyme Inhibitor using the OpenPlex™ system
The use of low molecular weight molecules in the industries of drug discovery and agri-food has become increasingly important over the course of a century of drug research and science development in agriculture and in pharmaceutical field.
Raman Analysis and characterization of pharmaceuticals
Polymorphy in pharmaceuticals by Raman Spectroscopy
Investigating the atherosclerosis process by monitoring lipid deposits including cholesterol and free fatty acids
Characterization and mapping of active pharmaceutical ingredients and excipients in a tablet using Raman and IR spectroscopy
Raman Microscopy in Pharmaceutical Salt Analysis
Raman Microscopy in Pharmaceutical Salt Analysis
Pharmaceutical and crystallographic samples typically require detailed characterization and analysis to optimize a samples stability, physical properties and indeed general efficacy where an active drug substance is involved.
Liposome Particle Size Determination
Liposomes are bilayer vesicles made of phospholipids derived from natural or man-made materials. They are mainly used in the pharmaceutical field for treatment of cancers as carriers of chemotherapeutic drugs to the tumor area.
Kinetic Fluorescence Determination of Vitamin B1
This technical note describes kinetic fluorescence as an analytical technique to quantify non-fluorescent species. The technique is applied to the determination of thiamine (vitamin B1) in solution.
Char of Compounds in a pharmaceutical drug product