Drug Discovery and Development

HORIBA supports the discovery and development of drug products by pharmaceutical industries, which require an extraordinary amount of time and effort to get to the final delivery to customers. During its entire lifecycle, the quality of the pharmaceuticals is one of the most critical steps, as it continually faces challenges from government and regulatory agencies to ensure quality and efficacy. From drug discovery to post-marketed products, HORIBA provides fast and innovative characterization solutions for all the scientific fields involved.

Browse Application

Production of a rescued recombinant monoclonal antibody directed against a steroid hormone and its binding study thanks to Surface Plasmon Resonance imaging technology
Production of a rescued recombinant monoclonal antibody directed against a steroid hormone and its binding study thanks to Surface Plasmon Resonance imaging technology
A monoclonal antibody (mAb) highly specific to a steroid hormone (undisclosed) of 290 Daltons was analyzed thanks to SPRi technology. This application note highlights the sensitivity of the XelPleXTM system for the detection of small molecules.
Raman Hyperspectral Imaging: An essential tool in the pharmaceutical field
Resulting from the combination of Raman spectroscopy and optical microscopy, Raman hyperspectral imaging has proven to be an indispensable tool in the pharmaceutical field. This article will broach a number of Raman hyperspectral imaging applications that were developed in our laboratory, in order to demonstrate the significance of the technique.
Validation of the activity of G-protein-coupled receptors (GPCRs) using SPRi
The Detection of a Low Molecular Weight Enzyme Inhibitor using the OpenPlex™ system
The Detection of an Ultralow Molecular Weight Enzyme Inhibitor using the XelPleX system
Raman Analysis and characterization of pharmaceuticals
Polymorphy in pharmaceuticals by Raman Spectroscopy
Investigating the atherosclerosis process by monitoring lipid deposits including cholesterol and free fatty acids
Characterization and mapping of active pharmaceutical ingredients and excipients in a tablet using Raman and IR spectroscopy
Raman Microscopy in Pharmaceutical Salt Analysis
Raman Microscopy in Pharmaceutical Salt Analysis
Pharmaceutical and crystallographic samples typically require detailed characterization and analysis to optimize a samples stability, physical properties and indeed general efficacy where an active drug substance is involved.
Kinetic Fluorescence Determination of Vitamin B1
This technical note describes kinetic fluorescence as an analytical technique to quantify non-fluorescent species. The technique is applied to the determination of thiamine (vitamin B1) in solution.
Char of Compounds in a pharmaceutical drug product