Investigating the atherosclerosis process by monitoring lipid deposits including cholesterol and free fatty acids

A mouse model for human atherosclerosis has been developed  in which the animals lack ApoE; these animals are called ApoE knock-out mice. These two measurements -the results of the aorta of an ApoE knock-out mouse and the results of the chemical study - indicate that the globule deposits contain cholesterol dissolved in fatty acid, and thus can be used as an early indicator of the atherosclerosis process in animal models during drug development.

Investigating_the_atherosclerosis_process_by_monitoring_lipid_deposits_including_cholesterol_and_free_fatty_acids.pdf
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