The Detection of an Ultralow Molecular Weight Enzyme Inhibitor

using the XelPleX™ system

Detection of low molecular weight molecules can be useful especially for pharmaceutical and agri-food applications. This application note is focused on the detection of a 157 Dalton molecule, the benzenesulfonamide, using the XelPleX system. XelPleX™ is the new generation of label-free interaction analysis platform.

The benzenesulfonamide is an inhibitor of the human carbonic anhydrase enzyme type II (CAII). The CAII catalyzes the hydration of carbon dioxide. Its role is to maintain acid-base balance in blood and tissues. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Renal CAII allows the reabsorption of sodium ions in the proximal tubule.

 

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