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Protein Aggregation: Monitoring the Size and Concentration

So we know protein aggregation is an important concern when developing and manufacturing biotherapeutics since subvisible aggregate particles have been associated with the adverse drug reactions. Find out how the multi-laser nanoparticle tracking analysis (NTA) approach allows polydisperse samples and much larger range of particle sizes to be visualized.

In this application note, we’re sharing with you the extensive work we’ve done:

  • Thermal Aggregation: Lysozyme
  • Concentration Induced Aggregation: BSA
  • Shear Induced Aggregation: mAb
  • Time Study: Drug Candidate Formulation

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