Particle Characterization of Pharmaceutical Powder Mixtures

powder mixtures (count, size and chemistry)

For the study of a pharmaceutical drug product, particle characteristics (count, size and chemistry) and compound distributions (size and spatial) are among key parameters that strongly determine the quality of the product due to their  huge impact on the dissolution rate (and thus bioavailability) for the final solid dosage form.  Monitoring these characteristics is critical in raw materials, interim mixtures during processing, and final products. In this application note, a powder mixture similar to an interim mixture of a pharmaceutical product was used. Laser diffraction and Raman microscopy were applied to highlight the benefits of combining two technologies for particle characterization.

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