nanoPartica SZ-100V2 Series*


Nanoparticle Analyzer

A highly advanced analyzer solves the mysteries of the nano-world. A single device analyzes the three parameters that characterize nanoparticles: particle size, zeta potential, and molecular weight.

Nanotechnology research and development is a continuously evolving effort to control substances at the atomic and molecular level in order to achieve new and better materials and products. The miniaturization of components – that is, control at the nano-level – is necessary to achieve faster, higher-performance devices and functions and to reduce energy consumption. Nanotechnology has come to play a key role in wide-ranging fields that affect our daily lives, including food, cosmetics, and the life sciences.

Clear and simple multi-parameter analysis of nanoparticles!

Three analyzers in a single compact body deliver high-sensitivity, high-accuracy analysis of each measurement parameter.

*Available in select countries

Segment: Scientific
Manufacturing Company: HORIBA, Ltd.

Particle Size Measurement Range 0.3 nm to 10 µm

The SZ-100V2 Series measures particle size and particle distribution width by dynamic light scattering (DLS).
Analysis across a wide range of sample concentrations: Measurement of samples ranging from low ppm-order concentrations to high-concentration samples in double-digit percentages is possible. Accepts commercially available sampling cells. Analysis of small-volume samples is also possible.

Zeta Potential Measurement – 500 to + 500 mV

Analysis of sample volumes as small as 100 μL using HORIBA-developed microelectrophoresis cells. Use the value of zeta potential to predict and control dispersion stability. High zeta potential magnitudes indicate a stable dispersion, useful for formulation work.

Molecular weight 1 × 103 to 2 × 107 Da

Absolute molecular weight (Mw) and the second virial coefficient (A2) are obtained by performing static light scattering measurement as a function of sample concentration and preparing Debye plots.

The SZ-100V2 Series applies sophisticated intelligence and learning capability to rapidly determine nanoparticle properties!

  • Since the SZ-100V2 Series analyzer covers a wide sample concentration measurement range, sample dilution and other preprocessing is nearly eliminated.
  • The use of a dual optical system enables measurement of high-concentration samples such as slurry and ink pigments as well as low-concentration proteins and polymers.
  • A single device analyzes the three parameters that characterize nanoparticles: particle size, zeta potential, and molecular weight.
  • HORIBA-developed disposable cells for zeta potential measurement prevent sample contamination.
    Simple analysis by means of ultra micro-volume dedicated cells (volume as low as 100 μL). Suitable for analysis of dilute samples.
  • HORIBA-developed electrode for zeta potential cell made from carbon material, the material is not corroded by high salt samples such as saline.

­SZ-100-S2 Measurement Specifications


SZ-100-S2 (particle size and molecular weight measurement only)

Measurement principles

Particle size measurement: Dynamic Light Scattering
Molecular weight measurement: Debye plot method (static scattered light intensity)

Measurement range

Particle size: 0.3 nm to 10 μm
Molecular weight: 1000 to 2 x 107 Da (Debye plot)
                             540 to 2 x 107 Da (MHS Equation)*1

Maximum sample concentration

40 wt%*2

Particle size measurement accuracy

Measurement accuracy of ±2% for NIST traceable polystyrene latex
100 nm spheres (not including variation in the standard particles themselves)

Measurement angles

90° and 173° (automatic or manual selection)



Measurement time

Approx. 2 min. under ordinary conditions
(from the start of measurement to the display of results for particle size measurement)

Required sample volume

Minimum volume of 12 μL*3 to 1000 μL (differs depending on cell material)

Usable liquids

Water, ethanol, organic solvents

*1: Mark-Howink-Sakurada Equation, depending on sample.
*2: Depending on sample.
*3: F Micro-cell.


SZ-100-Z2 Measurement Specifications
(Particle size and molecular weight measurement specifications are the same as for the SZ-100-S2.)


SZ-100-Z2 (with zeta potential measurement unit)

Measurement principle

Zeta potential measurement: Laser Doppler electrophoresis

Measurement range

-500 to +500 mV

Size range suitable for measurement

Minimum 2.0 nm, Maximum 100 μm*4

Measurement conductivity range

0 to 20 S/m*5

Maximum sample concentration

40 wt%*6


Dedicated cell with electrodes

Measurement time

Approx. 2 min. under ordinary conditions

Required sample volume

100 μL

Carrier fluids


*4: Depending on sample.
*5: Recommended sample conductivity range: 0 to 2 S/m.
*6: Depending on sample.


Analyzer Specifications (SZ-100-S2 and SZ-100-Z2)

Measuring unit optical system

Light source: Diode pumped frequency doubled laser (532 nm, S2 / Z2 10 mW, HS2 / HZ2 100 mW)
Detectors: Photomultiplier tubes (PMT)

Laser classification

Class I

Operating temperature and humidity

15 - 35 °C, RH 85% or less (no condensing)

Holder temperature control temperature settings

0 - 90 °C (up to 70 °C for cells with electrodes and plastic cells)


Dry gas purge port tube connection is possible.

Power supply

AC 100 - 240 V, 50/60 Hz, 150 VA


528 (W) x 385 (D) x 273 (H) mm (excluding protrusions)


25 kg

Personal computer

Windows computer with one available USB port


USB 2.0 (between measuring unit and PC)


Windows® 10 32/64 bit

Dimensions (mm)



Particle size cells

 Cell nameMin volumeSolvent
ADisposable cell1.2 mLAqueous
BSemi-micro cell500 µLAqueous, non-aqueous
CGlass cell1.2 mLAqueous, non-aqueous
DSemi-micro disposable cell600 µLAqueous
ECell with lid1.2 mLAqueous, non-aqueous
FMicro cell (90° only)12 µLAqueous, non-aqueous
GSub-micro cell200 µLAqueous, non-aqueous
HFlow cell100 µLAqueous, non-aqueous


Zeta potential cells

Zeta potential cells
Disposable zeta potential cells for aqueous measurements. Box of 20 Volume = 100 µL

Disposable zeta potential cells
Non-aquoeus zeta potential cell. Volume = 100 µL

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