Particle Analysis in Vaccine Manufacturing and Development
Size matters in vaccine delivery systems. Nanoparticles smaller than 200 nm generally present a greater immunogenic response than micro-particles larger than 1 micron.
ViewSizer 3000
Multi-Laser Nanoparticle Tracking Analysis (NTA)
Exosomes? Virus? Nanoparticle? Use multiple lasers for complete, detailed analysis of all the particles in your sample.
Exosomes, viruses, and nanoparticles all have wide size distributions which defeat traditional Nanoparticle Tracking Analysis (NTA) analyzers. The ViewSizer 3000 features simultaneous measurement with three lasers to collect the most accurate distribution and concentration information over a wide range of sizes within the same sample. Where the signal from a particle is too bright and saturates the detector from one laser, the software automatically uses data from a lower power laser to ensure the most accurate size and concentration information. On the other hand, when scattering from one laser is too weak for detection, the software uses data from a higher power laser to accurately track the particle.
Cross contamination is a concern in all analyses. Simplified cleaning means thorough cleaning. The easy-to-remove sample cells can be dissassembled for rapid, thorough cleaning, which leads to better data.
Escape the limits of traditional NTA
Accurate and sensitive analysis without cross contamination
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Segment: Scientific
Division: Particle Characterization
Size Measurement Range: 10 nm to 15 microns depending on sample
The ViewSizer determines particle size and size distribution details by multi-laser nanoparticle tracking analysis (NTA). Multiple lasers enable analysis of a broad range of sizes in the same sample.
Concentration Measurement Range: 5 x 106 to 2 x 108 particles/mL
NTA can be used to count particles in the measurement volume. A patented method corrects for the effect of particle size on effective measurement volume.
No cross-contamination
The sample cell can be completely removed and dissassembled for complete cleaning. Disassembly, cleaning, and reassembly is faster than rinsing a flow cell. Furthermore, multiple cells can be used for faster throughput or assigned to various groups in a shared (core) facility.
The ViewSizer 3000 uses the latest advances in nanoparticle tracking analysis (NTA) to accurately determine particle properties!
Measurement Range | 10 nm to 15 μm |
|---|---|
Typical Sample Volume | 350 µL to 1.25 mL |
Typical Sample Concentration | 5 x 106 to 2x108 particles/mL |
Sample Temperature Range | 10° C to 50° C +/- 0.1° C |
Dimensions | 55 cm W x 66 cm D x 35 cm H |
Weight | 27 kg |
Operational Environment | 15° C to 30° C with < 85% RH |
Accurate Protein Aggregation Analysis
Protein aggregation is an important concern when developing and manufacturing biotherapeutics. It is important to quantify protein aggregation and particle formulation as this data is needed to guide formulation development, evaluate handling requirements, and monitor product quality.
Nanoparticle Analysis
Nanotechnology is extremely diverse, ranging from novel extensions of conventional device physics, to completely new approaches based upon molecular self-assembly and to developing new materials with dimensions on the nanoscale. Materials reduced to the nanoscale can show different properties compared to what they exhibit on a macroscale, enabling unique applications.
Distribution and Concentration of Exosomes
In this study, we demonstrate the ViewSizer 3000’s capabilities as a next generation NTA based analysis instrument in order to accurately and efficiently measure and characterize exosomes via particle size and concentration.
Characterization of Sub-Visible Particles in Protein Therapeutic Formulations
The ViewSizer™ 3000 enables scientists to visualize and quantify the kinetics of protein aggregation in real-time for biologic therapeutics under a variety of stress conditions.
