Plasmacell
- Size : Small to medium, 10-15 µm
- N/C ratio= Medium
- Cytoplasm
- Extension : Abundant
- Basophilia : Intense
- Number of granules : Absent
- Color of granules : N/A
- Membrane : Regular
- Nucleus
- Situation : Eccentric
- Chromatin : Coarse
- Nucleoli : Absent
- Membrane : Regular
- Normal values : Absent in the blood, present in the bone marrow (<5%)
- Description / Pathology :
Small to medium oval cell with well-defined outline, round eccentric nucleus, highly condensed chromatin with tortoiseshell appearance. Intensely basophilic cytoplasm with Golgi apparatus adjacent to the nucleus
Multiple myeloma (> 10% bone marrow plasma cells associated with a monoclonal peak and suggestive clinical signs such as anemia, renal failure, hypercalcemia, bone lesions). Very rare plasma cell leukemia. MGUS (<10% in the bone marrow) without clinical signs.
In low numbers in the mononucleosis (<2%) associated with many hyperbasophilic lymphocytes.