Eosinophil metamyelocyte

Eosinophil_metamyelocyte
  • Size : 15-20 µm
  • N/C ratio= Low, = 0.3
  • Cytoplasm
    • Extension : Abundant
    • Basophilia : Absent
    • Number of granules : Numerous
    • Color of granules : Orange = eosinophil
    • Membrane : Regular
  • Nucleus
    • Situation : Eccentric
    • Chromatin : Dense
    • Nucleoli : Absent
    • Membrane : Regular
  • Normal values : Absent in the blood, rare in the bone marrow
  • Description / Pathology :

    Large size cell, curved nucleus, dense chromatin, clear cytoplasm but covered by eosinophilic granules (orange, thick and with the shape of a bead bag).

    Primitive Hypereosinophilic syndrome (HES): quantity increased with atypia (hypogranulation, fine granules, often associated with recurrent molecular abnormality, the most common is FIP1L1-PDGFRa.) Other eosinophilia: allergic, parasitic infection.

    Eosinophilia associated with hematological malignancies: T-cell lymphoma, Hodgkin disease, chronic myeloid leukemia.

Corporate