Yumizen H500 Hematology Analyzer
November 2025 (PDF for print)
Patient Demographics: Male, 6 years old
Symptoms: Fever and generalized weakness
Diagnosis: Acute Lymphoblastic Leukemia (ALL) – B-cell type, confirmed by immunophenotyping and molecular cytogenetics
Microscopic Review: Blasts: 88%, Neutrophils: 3%, Lymphocytes: 9%. Peripheral blood smear revealed small to large heterogeneous blast cells with irregular nuclear shapes, frequent clefting, and inconspicuous to prominent nucleoli.
How Yumizen H500 Assisted: The HORIBA Yumizen H500 raised an alarm for “Blast” suspicion and flagged suspected pathologies, prompting a review for large immature cells and atypical lymphocytes. On the DIFF scattergram, a lymphoblast population was observed in the atypical lymphocyte area, corroborated by extended immature WBC differential values (ALY & IML).This advanced feature, available on a mid-range hematology analyzer, enables mid-segment laboratories to support early diagnosis and intervention—crucial for managing challenging cases like childhood leukemia at the primary care level.
This clinical case has been provided by Hematology Lab, Mumbai, India.
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