Biomarker Discovery using Surface Plasmon Resonance Imaging

By: Elodie LY-MORIN, Sophie BELLON, Geraldine MELIZZI, Chiraz FRYDMAN

24 September 2012


Surface Plasmon Resonance (SPR) is an optical technique used to follow molecular interactions (binding) in real time without labeling. It provides information on kinetic processes (association and dissociation rates), binding affinity, analyte concentration and real time molecule detection. This article describes the principle of SPR imaging for high-throughput measurements. An example of a clinical application for the capture and characterization of a potential biomarker of breast cancer is illustrated.

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