What is a CS surface chemistry?

The CS surface chemistry is suitable for immobilizing molecules with an amine function (NH2 group). The immobilization principle is based on the high affinity of sulfur atoms in POE molecules (POE = polyoxyethylene) on gold. Free carboxylic acid functions of POE are then activated by a NHS:EDC solution (NHS = N-Hydroxysuccinimide, EDC = 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide). Activated carboxylic acids can then react with free amine functions of the ligand to create amide functions.

Principle of a CS chemistry
Principle of a CS chemistry