Studying heart disease by simultaneous measurement of changes of Sarcomere Length and concomitant intracellular ionic calcium concentration in freshly isolated cardiac myocytes.
From a pathophysiological perspective, the HORIBA Ratiomaster RM-50 with the Sarcomere Length measurement module enables investigators to directly assess whether cardiac dysfunction associated with cardiovascular diseases is mediated by alterations in cardiomyocyte free ionic Ca2+ concentration resulting in impaired cardiomyocyte contractility. This may be of particular importance in drug discovery and screening of novel compounds that may activate, or inhibit, specific signaling pathways in the heart and may be useful as a novel therapeutic strategy for improving cardiac function in a variety of cardiomyopathies. The Ratiomaster RM-50 is designed to measure and quantify calcium transients and cell contractility of fura-2 loaded cardiomyocytes. The system is capable of high sensitivity, high speed readout (1000 fps) of contrast edge changes and is based on a sensitive PMT photometer for detection of single photon fluorescence.
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