Pharmacology Toxicology and Pharmacy

Pharmacology, Toxicology and Pharmacy provide a starring role in the medicines and treatments that keep us healthy. HORIBA clinical chemistry and Raman technology help to understand the properties of drugs and medicine from design to formulation. Our steady state and lifetime bench-top spectrofluorometer FluoroMax® series and Yumzen range assist with disease and drug action through biology and pharmacology. HORIBA’s cutting-edge technology supports the insight into drug and toxicant action at the molecular level along with the interactions of chemicals with biological effects.

Interest of the Month

QSP Newsletter_October 2020_HORIBA Medical_EN

QSP Newsletter #6

QSP Monthly Newsletter of the Quality Slide Program

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Raman Microscopy: A must for pharmaceutical product analysis, from formulation studies to QC

The development of a new drug product is a long road in the pharmaceutical industry. Understanding active pharmaceutical ingredients (APIs) and compound spatial distributions, investigating final product homogeneity, and differentiating chemically similar molecules such as polymorphs are constant challenges when working to guarantee product quality and process efficiency.

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Applications

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Rapid and Reliable Zinc Determination in Liquid Using a Compact Benchtop EDXRF
We introduce EDXRF analysis as a rapid and reliable method for Zinc determination in liquid solution. We demonstrated Zn determination at ppm levels using the calibration curve method with commercial Zinc liquid standard samples. Our calibration curve had a good linearity (R2 > 0.999) and we could accurately determine 22 ppm of Zn in 1 minute. The results demonstrated that EDXRF is an effective tool for rapid and reliable laboratory analysis.
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Raman spectra of DayQuil™ and NyQuil™ collected with an immersion probe fiber-coupled to the MacroRAM™ Raman spectrometer, and a picture of the immersion probe setup.
Quantitative Analysis Using Raman Spectroscopy in Pharmaceutical Applications
Raman spectroscopy is well known as a powerful analytical method for qualitative chemical analysis. Less well known is that under certain conditions Raman spectroscopy can also be an effective method for quantitative analysis. Here we demonstrate that capability for quantitative analysis under a variety of conditions, involving different solutes in a solution and solution mixtures, and its applications to pharmaceutical analysis such as content uniformity.
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Monitoring Biotinylated Adeno-Associated Virus (AAV) using A-TEEM
Monitoring Biotinylated Adeno-Associated Virus (AAV) using A-TEEM
Adeno-Associated Viruses (AAVs) are becoming widely used as viral vectors to deliver cell and gene therapies and vaccines. As production methods scale to meet growing demand, more information is needed more quickly.
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Application note: Morphological and chemical characterization of pharmaceutical formulations
Morphological and chemical characterization of pharmaceutical formulations
In order to control formulations of pharmaceutical products, characterizing their active compounds is critical, especially in terms of morphological and chemical characterization of particles. In this application note, two formulations from a generic and an innovator nasal spray have been analyzed to compare their compounds size and shape, and chemically characterized to compare the two formulations based on the ParticleFinderTM app for LabSpec 6. A focus is done on the active compound.

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