Nutraceutical Applications

Nutraceuticals are food extracts that have been demonstrated to produce a physiological benefit or provide some protection against chronic disease. As the name implies, nutraceuticals are the intersection of nutrition and pharmaceutical and is an umbrella term that can also include functional foods and dietary supplements.

Nutraceuticals possess a “cure preference” over pharmaceuticals owing to cultural shifts towards naturally derived goods and drugs. Additionally, the typically high cost of pharmaceutical drug discovery (which in turn leads to high cost prescription drugs) is mitigated given the narrowed scope of active nutraceutical ingredients. Many foods already provide empirical evidence of imparting disease resistance to the consumer. To this end nutraceutical, pharmaceutical, and biotechnology companies have committed billions of dollars towards the research and development of commercially available foodstuffs such as omega-3 fatty acids that are both biocompatible and bioavailable.

The Role of Particle Characterization

Nutraceutical compounds do not yet fall under the same regulatory guidelines and control known to the pharmaceutical industry, but many of the same analytical studies are conducted. Quantitative particle size, particle shape, and zeta potential analysis provides information that has either a direct effect or correlation to issues such as bioavailability, solubility, formulation stability, and quality control.

Several promising nutraceutical materials are included as case studies in the Nutraceutical Application Note (You need to be logged in). Among them are examples of identifying unwanted contaminants, comparing different formulations for particle size and bioavailability, and increasing solubility of a material via particle size reduction and the resultant increase in specific surface area.

Instrumental Techniques

Nutraceutical researchers working to improve the bioavailability, biocompatibility, and stability of various formulations measure particle size, particle shape, and zeta potential. Various techniques are now capable of measuring particle size in the nanometer, micrometer, and millimeter size ranges. These techniques include laser diffraction, dynamic light scattering (DLS), static image analysis, and acoustic spectroscopy. The LA-960 laser diffraction particle size analyzer is the best choice when measuring many materials occupying different size ranges and requiring fast, flexible analyses. The SZ-100 dynamic light scattering nanoparticle size analyzer provides size information for nano scale suspensions and emulsions through a simple, robust user interface. The PSA300 image analysis system reports the particle size and shape distributions of nutraceuticals from 0.5 to 1000µm using an automated optical microscope. The DT-1201 acoustic spectrometer measures both the particle size and zeta potential of nutraceutical dispersions without dilution.

Contact the Particle Experts at HORIBA to talk about your application and which technique and analyzer would best fit your company’s needs.

Additional Applications

Particle Analyzers for Nutraceutical Applications

LA-960

The LA-960 uses Mie Scattering (laser diffraction) to measure particle size of suspensions or dry powders. The speed and ease-of-use of this technique makes it the popular choice for most applications.

SZ-100 Nanopartica Series Instruments

Industry's widest range and highest precision measurement instrument for Nanoparticle characterization.

CAMSIZER Dynamic Image Analyzer

HORIBA's CAMSIZER features dynamic image analysis to provide rapid and precise particle size and particle shape distributions for dry powders and bulk material in the size range from 20µm to 30mm.

PSA300

The HORIBA PSA300 is a state of the art turn-key image analysis solution. Seamless integration of Clemex's powerful particle characterization software and an automated microscope with high resolution camera creates an intuitive, easy-to-use imaging workstation.

SA-9600 Surface Area Analyzer

HORIBA's breakthrough SA-9600 Series brings exceptional convenience and confidence to surface area and pore volume analysis. Now you can perform single-point surface area, multi-point surface area and total pore volume measurements with push-button ease.