The Sedat filter sets are recommended for multi-color applications and result in minimal image shift and increased signal-to-noise in comparison to standard multi-band and Pinkel sets. Single band excitation and emission filters are normally installed in automated filter wheels with a stationary multi-band dichroic in the microscope, for quick color changes. These sets were first conceived by Dr. John Sedat at UCSF. All sets have Zero Pixel Shift (ZPS™) as a standard feature.