Life Sciences

Providing sophisticated analytical tools to advance research, product development and quality in the Life Sciences industry

Life sciences or biological sciences mean areas of science that involve the scientific study of life, organisms and biomolecules. This huge field seeks to understand the complex and elaborate mechanisms that support life and helps preserve our lives by increasing the progress of Health (diagnostic analysis and treatment), the control of the environment, the analysis in pharmaceutical research and the quality control in agri-food. At HORIBA Scientific, we provide a wide range of breakthrough instruments and methods tailored to our customers to push the limits of imaginative science.

Browse Applications

The Detection of a Low Molecular Weight Enzyme Inhibitor using the OpenPlex™ system
SPRi Imaging of oligosaccharides proteins interactions
Protein-Peptide interactions studies with SPRi
Description of the advantages of combining the use of peptide chips with direct label-free detection as achieved by SPR imaging (SPRi).
Monitoring of interactions between aptamers and human IgE by SPRi
Label-free Ligand Fishing in Human Plasma
Interaction between immobilized peptides and protein from sera on Cystamine / Glutaraldehyde functionalized biochip
Insights into thrombosis mechanisms using high resolution SERS
How to quantify a protein in different crude samples in one run, using the XelPleX
Detection of birch pollen allergen in the air
Antibody-Antigen Specific interaction
SERS Analysis of single living lymphocytes
Effect of temperature on HSA structure inferred using timeresolved room-temperature phosphorescence
Selection of SpectraLED pulsed excitation sources
To access intrinsic amino acids, such as tryptophan, as probes, the UV excitation wavelengths for pulsed phosphorescence measurements have long been the preserve of low-repetition-rate gas-filled lamps or larger laser systems. Recent developments have enabled the use of interchangeable semiconductor diodes, with their inherent ease of use. SpectraLEDs provide spectral coverage from the UV to the near-IR.
Protein-Peptide interactions studies with SPRi
Description of the advantages of combining the use of peptide chips with direct label-free detection as achieved by SPR imaging (SPRi).
Label-free Ligand Fishing in Human Plasma
Stopped flow time‐resolved fluorescence study of serum albumin – curcuminoid binding
Rapid mixing accessories to perform stopped flow measurements have found application in characterizing interactions and reactions occurring in solution. Reactants are expelled from syringes, mixed and injected into a flowcell.
Dye‐protein binding monitored in a microliter volume using timeresolved fluorescence
The potential health benefits stemming from the antioxidant activity of curcumin, commonly found in turmeric (Curcuma longa L), has attracted the interest of several research groups.
The Detection of a Low Molecular Weight Enzyme Inhibitor using the OpenPlex™ system
SPRi Imaging of oligosaccharides proteins interactions
Protein-Peptide interactions studies with SPRi
Description of the advantages of combining the use of peptide chips with direct label-free detection as achieved by SPR imaging (SPRi).
Monitoring of interactions between aptamers and human IgE by SPRi
Label-free Ligand Fishing in Human Plasma
Interaction between immobilized peptides and protein from sera on Cystamine / Glutaraldehyde functionalized biochip
Detection of birch pollen allergen in the air
Antibody-Antigen Specific interaction
Stopped flow time‐resolved fluorescence study of serum albumin – curcuminoid binding
Rapid mixing accessories to perform stopped flow measurements have found application in characterizing interactions and reactions occurring in solution. Reactants are expelled from syringes, mixed and injected into a flowcell.
Plasmon enhancement of protein fluorescence by silver nanostructures
The use of metal surfaces in conjunction with fluorescence molecules employing a plasmon effect, sometimes referred to as metal enhanced fluorescence, can be advantageous because of the possible enhancement of photophysical properties. For example, the emission intensity of the fluorophore, can be improved.
Dye‐protein binding monitored in a microliter volume using timeresolved fluorescence
The potential health benefits stemming from the antioxidant activity of curcumin, commonly found in turmeric (Curcuma longa L), has attracted the interest of several research groups.
Selective excitation of tryptophan fluorescence decay in proteins using a subnanosecond 295 nm light-emitting diode and time-correlated single-photon counting
Raman Imaging of monkey brain tissue
Effect of temperature on HSA structure inferred using timeresolved room-temperature phosphorescence
Selection of SpectraLED pulsed excitation sources
To access intrinsic amino acids, such as tryptophan, as probes, the UV excitation wavelengths for pulsed phosphorescence measurements have long been the preserve of low-repetition-rate gas-filled lamps or larger laser systems. Recent developments have enabled the use of interchangeable semiconductor diodes, with their inherent ease of use. SpectraLEDs provide spectral coverage from the UV to the near-IR.
Raman and Resonance Raman Spectroscopy of Enzymes
Molecular structure of PNA photolyase binding in close proximity to FAD cofactor
The TRIAX and iHR series spectrometers used in Raman system configurations provide superior imaging performance with no re-diffracted light and maximized optical throughput. Coupled to a high-performance Symphony® or Synapse™ CCD detector, these systems provide a high-performance spectroscopy platform for the investigation of chemical structures and components.
MCS and Protein Phosphorescence
Multichannel scaling (MCS) single-photon-counting spectroscopy performed using HORIBA Jobin Yvon’s FluoroCube fluorescence lifetime system.
Tryptophan phosphorescence within protein molecules is gaining attention as a probe of protein dynamics and structure. The tryptophan phosphorescence lifetime, τ, varies with the protein molecule’s local environment and conformation. For example, τ decreases as the solvent viscosity rises. The lifetime also decreases as small molecules diffuse into the protein and quench tryptophan. Dr. Bruce Kerwin and colleagues at Amgen (Thousand Oaks, CA) and the Istituto di Biofisica (Pisa, Italy) have examined the quenching of tryptophan emission in N-acetyl tryptophanamide (NATA), human serum albumin (HSA), and recombinant HSA (rHSA) using the HORIBA Jobin Yvon FluoroCube lifetime spectrofluorometer, which is a sensitive and important tool for investigation of the properties of proteins and changes in these proteins’ microenviroments.
Detecting Conformational Rotamers via TCSPC
Detecting Conformational Rotamers via TCSPC
Fluorescent Pigments in Living Coral
The brightly-colored coral reefs that make scuba-diving and snorkeling so enjoyable are essential to the survival of much underwater life. Not only do reefs offer a haven for smaller fish to hide from larger predators, but also some fish actually survive by eating the reefs themselves. Reefs offer protection to plants and animals from the ravages of waves and ocean currents. Thus, when the reefs die, so do many other living creatures.
Real time detection of lymphocytes with SPRi
Raman Investigation of Micro-organisms on a single cell level
Raman Analysis of Single Bacteria Cells
Direct_identification_of_clinically_relevant_microorganisms
Characterization of DNA sensor pads using UVISEL Spectroscopic phase modulated Ellipsometer
Monitoring of interactions between aptamers and human IgE by Surface Plasmon Resonance imaging
Raman_Analysis_of_Sperm_Nuclear_DNA_Integrity
Rapid couplig of SPRi and proteinchip
Spectroscopic Ellipsometric measurements on biochip structures in a liquid flow cell environment
Visualizing local viscosity using fluorescence lifetime microscopy
DynaMyc with FLIM (fluorescence lifetime imaging)
Elucidating Local Viscosity Using Fluorescence Lifetime Measurements
Certain fluorescent molecules, known as molecular rotors, can be employed to estimate the local (nanoscale) viscosity in microheterogeneous systems by measurement of their fluorescence lifetime. This can be advantageous over the usual fluorescence anisotropy method, as the measurement is simpler and faster to perform. This is demonstrated using the HORIBA Scientific TemPro fluorescence lifetime system to monitor the gelation of silica produced using the sol‐gel technique.
Spectroscopic Ellipsometry Application in Life Science
In recent years, Spectroscopic Ellipsometry application is extended to the life science. In this article, we introduce two examples from this field: Biocompatibility of DLC films and demineralization and remineralization process of tooth surface.
Experimental Assessment of Metal Nanostructures as Effective SERS Substrates
Research in nanoscience has garnered much interest because of the different properties of small structures compared to the respective bulk material.
Photoluminescence of InGaAs/GaAs Quantum Dots
InGaAs/GaAs and InAs/GaAs quantum dots (QDs) have been identified as suitable candidates for various applications in the terahertz range by using their intraband carrier transitions.
The NanoLog Series: A New Generation of Performance
The NanoLog has a reputation as the premier instrument for the exploration of single-walled carbon nanotubes (SWCNTs).
Measuring Silica Nanoparticles via Fluorescence Anisotropy
Silica is currently one of the most important industrial materials, whose nanoparticles are formed via a sol-gel process.
Nanophotonics with Fluorescence Instruments
HORIBA Jobin Yvon’s spectrofluorometers have many applications in nanophotonics research: single-walled carbon nanotubes (SWNTs), quantum dots (QDs), and organic light-emitting diodes (OLEDs). Quantum confinement affects nanomaterials’ photoluminescence: when the semiconducting nanoparticle is smaller than the bulk material’s Bohrexciton radius, the bandgap energy is inversely proportional to the nanoparticle size.
Characterization of Engineered nanomaterials by Spectroscopic Ellipsometry
Photoluminescence Spectroscopy of Quantum Dots
Photoluminescence Spectroscopy of Quantum Dots
Quantum dots (QDs) have potential applications in optoelectronics, biosensing, biolabeling, memory devices, and sources of laser light.
Near-IR Photoluminescence of Quantum Dots
HORIBA Jobin Yvon’s NanoLog® spectrofluorometer, specially optimized for recording near-IR fluorescence from nanoparticles, includes a double-grating excitation monochromator, imaging emission spectrograph with a selectable-grating turret, and a variety of detectors.
Better Signal-to-Noise Ratios for Carbon Nanotube Spectra
Better Signal-to-Noise Ratios for Carbon Nanotube Spectra
Corrected emission spectra1 of carbon nanoparticles can provide excitation–emission matrices (EEMs) for a range of excitation wavelengths.
Fluorescence Spectra from Carbon Nanotubes with the NanoLog
Fluorescence Spectra from Carbon Nanotubes
Single-wall carbon nanotubes (SWNTs), consisting of rolled-up single sheets of carbon atoms, have received much attention recently.
Spectroscopic Ellipsometry Application in Life Science
In recent years, Spectroscopic Ellipsometry application is extended to the life science. In this article, we introduce two examples from this field: Biocompatibility of DLC films and demineralization and remineralization process of tooth surface.
Visualizing dental caries using fluorescence lifetime microscopy
Teeth are naturally fluorescent and changes in their composition, caused by decay for example, affect their fluorescence behavior.
Assessing UV Damage of Hair with Fluorescence
Fluorescence from hair

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