Biopharma and Pharma

Drug Development and Formulation

With High Throughput Screening, spectroscopy techniques like UV-Vis, fluorescence, and Raman are used to screen large libraries of compounds for potential drug candidates based on their interaction with target molecules. It helps determine the structure of newly discovered molecules, which is essential for understanding their properties and potential therapeutic effects. Spectroscopic techniques can be used to study the interaction between drugs and their targets, providing valuable information on the mechanism of action and potential side effects. Finally, spectroscopy helps optimize the formulation of drugs by investigating interactions between drug molecules and excipients, ensuring stability and efficacy. Spectroscopic techniques provided by HORIBA, combined with Particle Size Analysis are widely used in determining Critical Quality Attributes (CQA). 

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Browse Application Notes

The Detection of a Low Molecular Weight Enzyme Inhibitor using the OpenPlex system

The use of low molecular weight molecules in the industries of drug discovery and agri-food has become increasingly important over the course of a century of drug research and science development in agriculture and in pharmaceutical field.

This application highlights the development of an oligosaccharide chip (surface functionalization, density of immobilization, spacer arm length) on the same SPRi platform using conductive polymers. These results are highlighted through the example of interactions between HS and SDF-1 α chemokine.

TERS Characterization of phospholipid bilayers and detection of nanoparticles

This application reports on TERS characterization of binary phospholipid bilayer systems deposited onto a gold coated coverslip. Such samples are used as model samples for directly and chemo-selectively visualizing the distribution of a lipid constituent at the nanometer scale.

HORIBA provides the pharmaceutical industry, biotech companies and academic research laboratories with high performance instrumentation based on SPRi technology (Surface Plasmon Resonance imaging). To demonstrate the power of this technology, we carried out an experiment based on an antibody-antigen interaction. Original surface chemistry combined with an electrochemical process allows the rapid coupling of biomolecules to the gold layer (polypyrrole co-polymerisation) on the top of a glass prism.

Nanoparticles used for drug delivery is an important research field combining the life sciences with nanotechnology. While the strict definition of a nanoparticle is between 1 – 100 nm, we can extend the upper size range in the context of this application up to approximately 500 nm. Laser diffraction provides the advantage of being able to measure larger particles.

Considerable research has been conducted exploring the use of nanoparticles composed of biopolymers as a drug delivery vehicle. Much of the particle size analysis in this field has been done using dynamic light scattering (DLS). However, certain materials will feature larger particles that are outside the upper size range of DLS, but within the capability of laser diffraction.

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HORIBA Solutions

PoliSpectra® RPR for HTS

PoliSpectra® RPR for HTS

Rapid Raman Plate Reader – Multiwell Fast Raman screening

XploRA™ PLUS

MicroRaman Spectrometer - Confocal Raman Microscope

Aqualog - A-TEEM Industrial QC/QA Analyzer

Aqualog - A-TEEM Industrial QC/QA Analyzer

A Simple, Fast, “Column Free” Molecular Fingerprinting Technology

ViewSizer 3000

Simultaneous Multi-Laser Nanoparticle Tracking Analysis (NTA)

Duetta

Fluorescence and Absorbance Spectrometer

MacroRAM™

Affordable Benchtop Raman Spectrometer

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Watch Webinars and Videos

The large variety of fluorescent probes, such as organic dyes, biological biotags and fluorescent nanostructures, are intensively studied due to their inherent suitability for a wide range of life science applications. Thanks to the complementary nature of its analytical solutions, HORIBA's unique offer covers fluorescence, particle analysis, AFM, Raman and XRF characterization techniques, helping to gain valuable insight into optical properties, size, morphology and composition of your bioprobes.

New camera, new imaging, new FLIM

Fast auto sampling. Auto fast sampling. Auto sampling, fast

A-TEEM™ stands for simultaneous Absorbance, Transmission, and Fluorescence Excitation-Emission-Matrix (EEMs) Acquisition.

Byron Purse on his work modifying Fluorescence of DNA & RNA

The simple and ideal excitation sources for TCSPC

EzSpec Software for Duetta and its winning user experience

Money down on this Head 2 Head EEM acquisition comparison

A-TEEM acquires chemical ID with fluorescence spectroscopy

Automatically discover Fluorescence profiles in about 60 seconds

EzSpec and its apps, making research too EZ

One of those things that make EzSpec so good

Automatically discover Fluorescence profiles in about 60 seconds

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