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HORIBA Chase the Case #54 - Urinary Tract Infection
A severe urinary tract infection case with leukocytosis insights. Learn how the Yumizen H2500 aids rapid detection, diagnosis, and clinical decision‑making.
March 2026 (PDF for print)
Patient Demography: Female, 46 years old
Diagnosis: Clinical picture suggestive of a severe urinary tract infection progressing toward urosepsis
Clinical Presentation: High fever (≥ 38.5 °C), chills, tremors, and lower back or flank pain typically associated with pyelonephritis, along with dysuria characterized by pain and burning during urination
Microscopic Review: 10% band neutrophils, 78% segmented neutrophils, 6% lymphocytes, 6% monocytes
Other Tests: CRP 283, Urinalysis: Protein: positive, Occult blood: positive, White blood cells: >100,000
How Yumizen H2500 can assist: On the DIFF scattergram, we observe marked neutrophilia and significant leukocytosis — findings consistent with a severe infectious process. The Yumizen H2500 provides critical information for the rapid identification of severe infections. The analyzer‑generated alarms — including “WBC Abnormal (Diff)” — guide the need for manual microscopic review, ensuring that qualitative abnormalities (such as the presence of band neutrophils and a left shift, also evidenced by an increased LIC) are confirmed by the analyst. Rapid and reliable quantification of leukocytosis, combined with the altered differential profile, supports clinicians in the early detection of a potential septic condition, enabling prompt therapeutic actions such as initiation of antibiotic therapy, vigorous hydration, or hemodynamic monitoring.
This clinical case has been provided by a laboratory in Brazil.
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