On-line TOC analyzer

High-precision continuous measurement of TOC in water used for pharmaceutical manufacturing and similar applications.

HT-110 is a TOC analyzer designed for water used in pharmaceutical manufacturing, which adopts the continuous UV oxidation and conductivity method as the measurement principle. In compliance with the USP (U.S. Pharmacopeia) reference standard, it is characterized by its ability to continuously measure low-concentration ranges, such as water for injection, with high accuracy.


Division: Process Water
Manufacturing Company: HORIBA Advanced Techno Co., Ltd.

Adoption of UV Oxidation Conductivity Method

The UV oxidation conductivity method, which eliminates the need for reagents and carrier gasses (purge gas) has been adopted. This method allows for high repeatability of ±2% F.S. for low-concentration ranges such as water for injection (WFI) at full scale while simultaneously providing a potential reduction in operating expenses.

Suppression of Erroneous Indications Caused by Air Bubble Inclusion

The equipment has a deaeration mechanism, which suppresses erroneous indications caused by the inclusion of air bubbles.

External control functions

By equipping contact input terminals, it is now possible to perform ON/OFF controls externally.  Useful for situations such as false alarms during SIP cleaning or nighttime shutdown of purified water equipment.

Maintenance cycle of one year

By significantly extending the lifespan of the UV lamp, maintenance is now reduced to a single annual calibration, allowing a maintenance-free period of one year.

Compatible with USP<643>, EP<2.2.44>, JP<G8.4.5.2>

Suitable for TOTAL ORGANIC CARBON measurement according to USP <643>, EP <2.2.44>, and for the suitability testing of "HIGHLY PURIFIED WATER", "WATER FOR INJECTION", and "WATER, PURIFIED" as per EP requirements. It is also ideal for the physicochemical monitoring specified in JP <G8.4.5.2> for PW (Purified Water) and WFI (Water for Injection).

Versatile installation options

The installation methods include pole-mounts, wall-mounts, and tabletops, allowing for flexible installation options tailored to the specific site requirements for versatile installations without limitations.

Product nameTotal organic carbon analyzer (TOC analyzer)
Measurement methodContinuous UV oxidation conductivity method
Measurement limit0 ppb to 1000 ppb
Measurement range0 ppb to 100/500/1000 ppb
RepeatabilityWithin ±2% of full scale
Display resolution0.1 ppb (0 ppb to 100 ppb/0 ppb to 500 ppb range)
1 ppb (0 ppb to 1000 ppb range)
Transmission outputNumber of output point: one
4 mA to 20 mA DC/0 V to 1 V DC (optional) insulated input/output
Maximum load resistance: 600 Ω (minimum load resistance 100 kΩ (when optionally selected))
Transmission output range: optional setting possible within measurement range
Output target: TOC concentration
Contact outputNumber of outputs: 2
Alarm contact output (RLY1)
Contact method: relay contact, SPDT (1c)
Contact capacity: 125 V 3 A AC/24 V 3 A DC (load resistance)
Contact function: upper/lower limit function (ON/OFF control)
Output target:
at TOC, temperature, conductivity:
C-NO contact is “closed” during operation, “open” during normal conditions
(including a POWER OFF state) *C-NO contact is reversed at hold, or error:
C-NO contact is “open” during operation (including a POWER OFF state),
“closed” during normal conditions *C-NO contact is reversed
Alarm contact output (RLY2)
Contact method: relay contact, SPST (1a)
Contact capacity: 125 V 3 A AC/24 V 3 A DC (load resistance)
Contact function: upper/lower limit function (ON/OFF control)
Output target: TOC concentration
Contact inputNumber of input point: 1
Non-voltage normal open (1a) signal input (open collector input possible)
Insulation-type input
Max. ON resistance: 50 Ω
Open-circuit voltage: 5 V DC
Max. short circuit current: 10 mA
An error will not be generated even if there is notification of no sample detection
immediately after receipt of the pure water device stop signal receiving
The hold operation during the contact input receiving.
Sample water conditionConductivity: less than 10 μS/cm (less than 2 μS/cm in 0 ppb to 100 ppb range)
Temperature: 5℃ to 99℃
Pressure: 0.03 MPa to 0.50 MPa,
Pressure fluctuation: within ±0.05 MPa (within the specified pressure range)
Flow rate: 20 mL/min to 200 mL/min
Environmental conditionsTemperature: 5℃ to 40℃
Relative humidity: less than 85%
InstallationInstall place: indoor
Display functionLCD (with a back light) TOC, conductivity, water temperature, alarm
Power100 V to 240 V AC ±10%, 50 Hz/60 Hz built-in fuse 250 V AC 3.15 A (T)
Power consumption80 VA (max.)
Outside dimension300 (W) × 400 (H) × 165 (D) mm
Mass13 kg
Concerned directivesCE markingEMC Directive: EN61326-2-3
Low Voltage Directive: EN61010-1
RoHS Directive: EN50581
FCC RuleFCC parts 15
Protection structureIP 43 (IEC60529, JIS C0920)
Pollution level 2 (IEC61010-1)

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