Applications

Overcoming Sensitivity and Resolution Challenges in Optical Characterization of Proteins with the HORIBA Fluorolog®-QM Spectrofluorometer

Characterization of protein-based samples utilizing fluorescence spectroscopy is fundamental to advancing our understanding of biomolecular structure, interactions, and dynamics, which are crucial for drug discovery, biophysics, and cellular biology. Yet, researchers face persistent challenges: many samples are inherently low in concentration, labeling can alter protein structure and function, and biological media often introduce significant scattering. Conventional spectrofluorometers, limited by low sensitivity and poor stray light rejection, struggle to deliver high-resolution spectra under these conditions.

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Overcoming Sensitivity and Resolution Challenges in Optical Characterization of Proteins with the HORIBA Fluorolog®-QM Spectrofluorometer
Characterization of protein-based samples utilizing fluorescence spectroscopy is fundamental to advancing our understanding of biomolecular structure, interactions, and dynamics, which are crucial for drug discovery, biophysics, and cellular biology. Yet, researchers face persistent challenges.
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