Eosinophil myelocyte
- Size : 18-20 µm
- N/C ratio= Medium, about 0.5
- Cytoplasm
- Extension : Abundant
- Basophilia : Slightly intense
- Number of granules : Numerous
- Color of granules : Orange = eosinophil
- Membrane : Regular
- Nucleus
- Situation : Eccentric
- Chromatin : Lacy
- Nucleoli : Absent
- Membrane : Regular
- Normal values : Absent in the blood, rare in the bone marrow (<2%)
- Description / Pathology :
Large size cell, with eccentric oval and not concave nucleus, no nucleolus, intermediate/mildly condensed chromatin, basophilic cytoplasm covered with large eosinophilic granules.
Hypereosinophilia
Primitive hypereosinophilic syndrome (HES): increased number with atypia: hypogranulation, fine granules often associated with recurrent molecular abnormality, the most common is FIP1L1-PDGFRa. Other reactive hypereosinophilia:allergic, parasitic infection
Hypereosinophilia associated with hematological malignancies: T-cell lymphoma, Hodgkin disease, chronic myeloid leukemia.