Monocyte

Monocyte
  • Size : 15-20 µm
  • N/C ratio= Low, = 0.3
  • Cytoplasm
    • Extension : Abundant
    • Basophilia : Slightly intense
    • Number of granules : Numerous
    • Color of granules : Red = azurophils
    • Membrane : Regular
  • Nucleus
    • Situation : Eccentric
    • Chromatin : Coarse
    • Nucleoli : Absent
    • Membrane : Regular
  • Normal values : Blood monocytes <1 x 10(9)/L
  • Description / Pathology :

    Large size cell, very irregular horseshoe- shaped nucleus, hammered-metal appearance or combed chromatin, no nucleolus, gray stormy sky cytoplasm, sometimes lipidic vacuoles and fine azurophilic granules.

    Reactive Monocytosis (most common cause).

    Acute monoblastic leukemia: AML5b> AML5a, Acute myelomonocytic leukemia AML4 (monocytes >5G/L or > 20% in the bone marrow).

    Chronic myelomonocytic leukemia CMML,Monocytosis associated with CML or other MPS.

Corporate