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Chase the Case #26

- Leukemia -

November 2023
(PDF for print)

Patient Demography: Male aged 56

Diagnosis: Possibility of Plasma Cell l Leukemia can be considered.

Microscopic Review: Atypical lymphocytes 37%. RBCs are predominantly normocytic normochromic. There is mild degree or anisocytosis. 2 nRBCs / 100 WBC seen. Few polychromatophilic cells seen. Marked leukocytosis with 37% atypical lymphocytes Plasma cell/ Plasmablast Round to oval, few with indented nucleus, occasionally binucleated, single prominent nucleus, abundant cytoplasm with hairy projections. Neutrophilic leukocytosis. Myeloid left shift i s seen. Mildly reduced by smear.

Other Information: I mmunophenotyping by flow cytometry, bone marrow aspiration and biopsy, serum protein electrophoresis and immunofixation, renal function test.

Chase_the_Case__26_Leukemia_Results

This clinical case has been provided by Dr. Islam Barkatullah Khan, Diveak Rustogi, Arvind, Rajeev Ranjan, Rocky, Redcliffe Labs, India

HORIBA Medical Chase the Case #26 - Leukemia

Understanding a rare hematological malignancy like Plasma Cell Leukemia from simple complete blood count (CBC) analysis by utilizing hematology analyzer cell data, scatter plot, and flagging system. HORIBA Medical's Yumizen Hematology systems are capable and equipped to perform sub-lineage white blood cells differentials like immature lymphocytes (IML), immature monocytes (IMM) and immature granulocytes (IMG) which can help in subclassification of hematology malignancy at preliminary stage, to further decide for specific confirmatory test for final diagnosis and accurate clinical management.

HORIBA Medical Chase the Case #15 - Acute Myeloblastic Leukemia

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