Pharmaceuticals and Medicine Manufacturing

The pharmaceutical and medicine manufacturing industry develops and produces a variety of medicinal and other health-related products that save the lives of millions of people from various diseases. This industry is primarily engaged in manufacturing biological and medical products, processing and isolating active medical principles from botanical drugs and herbs, manufacturing pharmaceutical products intended for internal and external consumption in such forms as tablets, capsules, ointments, powders and solutions.

HORIBA offers a large choice of innovative technologies such as Fluorescence spectroscopy, Raman spectroscopy, Surface Plasmon Resonance Imaging, Particle Size Analyzers, Capacitance manometer and gas monitor Micropole systems that contribute to the quality and performance of drugs manufacturing.

Browse Applications

Determination of the Roundness of Globules in the Pharmaceutical Industry
For determination of grain size and roundness of globules, quick and objective measurement methods are required to guarantee high analytical accuracy as well as high product throughput.
The Detection of a Low Molecular Weight Enzyme Inhibitor using the OpenPlex™ system
Particle Characterization of Nutraceutical Products
Laser diffraction particle size analyzers offer the same benefits in speed, precision, and reliability to nutraceutical materials that have made the technique popular in the pharmaceutical industry.
Determination of Particle Size and Shape of Pharmaceutical Granules
In this study, dynamic image analysis is used in the pharmaceutical industry to define the size and shape of granules created through a dry granulation process.
Size and Shape Characterization of Pharmaceutical Active Ingredients
API image taken by PSA300
This application note summarizes the reasons why static image analysis is becoming a popular technique for characterizing APIs.
Characterization of Sub-Visible Particles in Protein Therapeutic Formulations
Sub-visible Particles from ViewSizer 3000
The ViewSizer® 3000 enables scientists to visualize and quantify the kinetics of protein aggregation in real-time for biologic therapeutics under a variety of stress conditions.
Fast & Non-invasive Determination of Skin State
Fast and non-invasive determination of skin
Biological tissues contain chromophores that absorb light, as well as fluorophores that absorb and reemit light (fluorescence effect). Light absorption depends on the chromophores’ content and their distribution within the organic matter.
Analytical Chemistry in Pharmaceuticals and Medicine Manufacturing
Char of Compounds in a pharmaceutical drug product
Investigating photocleavage using time‐resolved emission spectra
The choice of protecting group is of crucial importance in the success of many steps in organic synthesis and the manipulation of polyfunctional molecules, since they can prevent the formation of undesired side products and reactions.
Vacuum Monitoring in Dryer Equipment for Freeze Dry in Pharmaceuticals and Medicine Manufacturing
Freeze Dry_Pharma
Particle Size Analysis of Cosmetics
Particle size analysis of cosmetics is used to study formulation, characterize raw materials, perform quality tests on end product, and potentially determine the amount of nano-particles in a product.
Valuable analysis tool for cosmetics and skin characterization
Confocal Raman Spectroscopy is an important analytical tool in various fields and it has shown high efficiency for specific applications in the cosmetic and/or pharmaceutical fields. Its non-invasive behavior, and its high molecular sensitivity make it one of the preferred label-free analytical techniques to characterize materials such as skin and cosmetic products.
Particle Size and Shape for Ointments and Creams
This study utilizes the PSA300 automated image analysis system to quantify the size and shape of various ointments and creams.
Fast & Non-invasive Determination of Skin State
Fast and non-invasive determination of skin
Biological tissues contain chromophores that absorb light, as well as fluorophores that absorb and reemit light (fluorescence effect). Light absorption depends on the chromophores’ content and their distribution within the organic matter.
Visualizing dental caries using fluorescence lifetime microscopy
Teeth are naturally fluorescent and changes in their composition, caused by decay for example, affect their fluorescence behavior.
Endogenous Skin Fluorescence In Vivo on Human Skin
The fluorescence spectra of intrinsic protein fluorophores have been studied extensively and used in investigating biological events.
Noninvasive In-Vivo Determination of Sunscreen-UVA Protection Factors
Noninvasive In-Vivo Determination of Sunscreen-UVA Protection Factors
The development and evaluation of UVA (320–400 nm) sunscreens is important because UVA sunlight can penetrate deep into human skin and cause severe internal damage, as well as erythema and photoaging.
In Vivo Raman measurements of Human Skin
Confocal Raman spectroscopy is beginning to be recognized as a high potential technique for the non invasive study of biological tissues and human skin under in vivo conditions. Raman spectroscopy can be applied to obtain information regarding the molecular composition of the skin down to several hundred micrometers below the skin surface.
Soap_compound_investigation_by_Raman_mapping
Determination of the Roundness of Globules in the Pharmaceutical Industry
For determination of grain size and roundness of globules, quick and objective measurement methods are required to guarantee high analytical accuracy as well as high product throughput.
The Detection of a Low Molecular Weight Enzyme Inhibitor using the OpenPlex™ system
Analysis of Biopolymers with Laser Diffraction
This application note describes two experiments where laser diffraction proved capable of determining both the base biopolymer nanoparticles and also larger particles outside of the range of DLS.
Characterization and mapping of active pharmaceutical ingredients and excipients in a tablet using Raman and IR spectroscopy
Raman Microscopy in Pharmaceutical Salt Analysis
Raman Microscopy in Pharmaceutical Salt Analysis
Pharmaceutical and crystallographic samples typically require detailed characterization and analysis to optimize a samples stability, physical properties and indeed general efficacy where an active drug substance is involved.
Determination of Particle Size and Shape of Pharmaceutical Granules
In this study, dynamic image analysis is used in the pharmaceutical industry to define the size and shape of granules created through a dry granulation process.
Pharmaceuticals_under_humidity_controlled_atmosphere
Particle characterization of pharmaceutical powder mixtures
Fluorescence on Small or Solid Samples
Samples can be valuable. Either you don’t want to waste them, or you may not have very much starting material. Biological proteins and enzymes, for example, are often obtained in small volumes and may be expensive.
Char of Compounds in a pharmaceutical drug product
Monitoring Cell Culture Media Variability using A-TEEM
Monitoring- Cell Culture Media Variability using ATEEM
With the rise of protein production using mammalian cell culture, it has become increasingly important to control the quality of the cell culture media for use in production processes. Cell culture media are usually prepared as aqueous solutions and should provide everything a cell line needs for optimal cell growth as well as product yield and quality.
The Detection of a Low Molecular Weight Enzyme Inhibitor using the OpenPlex™ system
Holistic Analysis of Mammalian Cell Proliferation using Fluorescence Spectroscopy
Holistic Analysis of Mammalian Cell Proliferation using Fluorescence Spectroscopy

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