Pharmaceuticals and Medicine Manufacturing

The pharmaceutical and medicine manufacturing industry develops and produces a variety of medicinal and other health-related products that save the lives of millions of people from various diseases. This industry is primarily engaged in manufacturing biological and medical products, processing and isolating active medical principles from botanical drugs and herbs, manufacturing pharmaceutical products intended for internal and external consumption in such forms as tablets, capsules, ointments, powders and solutions.

HORIBA offers a large choice of innovative technologies such as Fluorescence spectroscopy, Raman spectroscopy, Surface Plasmon Resonance Imaging, Particle Size Analyzers, Capacitance manometer and gas monitor Micropole systems that contribute to the quality and performance of drugs manufacturing.

Browse Applications

Raman Hyperspectral Imaging: An essential tool in the pharmaceutical field
Resulting from the combination of Raman spectroscopy and optical microscopy, Raman hyperspectral imaging has proven to be an indispensable tool in the pharmaceutical field. This article will broach a number of Raman hyperspectral imaging applications that were developed in our laboratory, in order to demonstrate the significance of the technique.
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Particle Size Reduction
Many particle size measurements are made to track size reduction operations such as milling, mixing, homogenizing, etc. Laser diffraction is the most common analysis technique for monitoring size reduction operations due to its very broad dynamic range.
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The Detection of a Low Molecular Weight Enzyme Inhibitor using the OpenPlex™ system
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Protein Aggregation Applications
The study of protein aggregation encompasses a broad range of interactions and mechanisms. The LA-960 laser diffraction particle size analyzer possesses the unique ability to measure from 10 nanometers to 5 millimeters, accurately detecting the aggregates and, in some cases, the primary protein size.
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Protein Applications
The size of a protein is an important physical characteristic that provides useful information including the presence of monomers, dimer and trimer, changes in conformation, aggregation state, and denaturation. Protein scientists typically discuss “protein size” or molecular weight, as opposed to using the phrase “particle size”, but particle size analyzers are often used in their studies.
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Pharmaceutical Aerosol Applications
Pharmaceutical aerosols including metered-dose inhalers (MDIs) and dry powder inhalers (DPIs) are devices that deliver a specific quantity of drug to the lungs. The particle size distribution and shape of the delivered dose is more critical for inhalation aerosols than for most other conventional drug products because these factors greatly influence the deposition profile in the lungs of the patient.
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Pharmaceutical Applications
The particle size distribution of active ingredients and excipients is an important physical characteristic of the materials used to create pharmaceutical products. The size, distribution and shape of the particles can affect bulk properties, product performance, processability, stability and appearance of the end product.
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Particle Size Analysis of Vitamins
Vitamins are classified by their biological and chemical activity, not by their structure. They are grouped under an alphabetized generic descriptor title such as vitamin A that includes the compounds retinal, retinol, and four carotenoids.
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Nutraceutical Applications
Nutraceuticals are food extracts that have been demonstrated to produce a physiological benefit or provide some protection against chronic disease. Nutraceuticals are the intersection of nutrition and pharmaceutical and can also include functional foods and dietary supplements.
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Char of Compounds in a pharmaceutical drug product
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Spectroscopic Methods for Sunscreens Characterization
This Application Note outlines three different kinds of spectroscopic tools being used for the characterization of sunscreens, and discusses the obtained results. These include Fluorescence spectroscopy for photoactivity, Particle Size analysis for composition and Raman microscopy for formulation investigation.
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Determination of the Roundness of Globules in the Pharmaceutical Industry
For determination of grain size and roundness of globules, quick and objective measurement methods are required to guarantee high analytical accuracy as well as high product throughput.
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Particle Characterization of Nutraceutical Products
Laser diffraction particle size analyzers offer the same benefits in speed, precision, and reliability to nutraceutical materials that have made the technique popular in the pharmaceutical industry.
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Determination of Particle Size and Shape of Pharmaceutical Granules
In this study, dynamic image analysis is used in the pharmaceutical industry to define the size and shape of granules created through a dry granulation process.
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Size and Shape Characterization of Pharmaceutical Active Ingredients
This application note summarizes the reasons why static image analysis is becoming a popular technique for characterizing APIs.
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Characterization of Sub-Visible Particles in Protein Therapeutic Formulations
The ViewSizer™ 3000 enables scientists to visualize and quantify the kinetics of protein aggregation in real-time for biologic therapeutics under a variety of stress conditions.
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Fast & Non-invasive Determination of Skin State
Fast and non-invasive determination of skin
Biological tissues contain chromophores that absorb light, as well as fluorophores that absorb and reemit light (fluorescence effect). Light absorption depends on the chromophores’ content and their distribution within the organic matter.
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Analytical Chemistry in Pharmaceuticals and Medicine Manufacturing
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Investigating photocleavage using time‐resolved emission spectra
The choice of protecting group is of crucial importance in the success of many steps in organic synthesis and the manipulation of polyfunctional molecules, since they can prevent the formation of undesired side products and reactions.
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Vacuum Monitoring in Dryer Equipment for Freeze Dry in Pharmaceuticals and Medicine Manufacturing
Freeze Dry_Pharma
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Spectroscopic Methods for Sunscreens Characterization
This Application Note outlines three different kinds of spectroscopic tools being used for the characterization of sunscreens, and discusses the obtained results. These include Fluorescence spectroscopy for photoactivity, Particle Size analysis for composition and Raman microscopy for formulation investigation.
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Cosmetic Applications
Many cosmetic products include particulate material or emulsions. Some examples of cosmetic products consisting of or including particulates include facial powders, moisturizers, and lipstick. The particle size distribution of these components effects appearance, stability, and protection.
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Valuable analysis tool for cosmetics and skin characterization
Confocal Raman Spectroscopy is an important analytical tool in various fields and it has shown high efficiency for specific applications in the cosmetic and/or pharmaceutical fields. Its non-invasive behavior, and its high molecular sensitivity make it one of the preferred label-free analytical techniques to characterize materials such as skin and cosmetic products.
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Particle Size and Shape for Ointments and Creams
This study utilizes the PSA300 automated image analysis system to quantify the size and shape of various ointments and creams.
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Fast & Non-invasive Determination of Skin State
Fast and non-invasive determination of skin
Biological tissues contain chromophores that absorb light, as well as fluorophores that absorb and reemit light (fluorescence effect). Light absorption depends on the chromophores’ content and their distribution within the organic matter.
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Visualizing dental caries using fluorescence lifetime microscopy
Teeth are naturally fluorescent and changes in their composition, caused by decay for example, affect their fluorescence behavior.
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Endogenous Skin Fluorescence In Vivo on Human Skin
The fluorescence spectra of intrinsic protein fluorophores have been studied extensively and used in investigating biological events.
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Noninvasive In-Vivo Determination of Sunscreen-UVA Protection Factors
Noninvasive In-Vivo Determination of Sunscreen-UVA Protection Factors
The development and evaluation of UVA (320–400 nm) sunscreens is important because UVA sunlight can penetrate deep into human skin and cause severe internal damage, as well as erythema and photoaging.
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In Vivo Raman measurements of Human Skin
Confocal Raman spectroscopy is beginning to be recognized as a high potential technique for the non invasive study of biological tissues and human skin under in vivo conditions. Raman spectroscopy can be applied to obtain information regarding the molecular composition of the skin down to several hundred micrometers below the skin surface.
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Soap_compound_investigation_by_Raman_mapping
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Pharmaceutical Sugar Spheres
Many solid oral dosage forms are based upon coating sugar spheres with layers of active ingredient, binders, and coatings. The size and shape of the beginning sugar spheres (also called nonpareil beads) are critical physical characteristics that should be carefully measured and controlled.
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Drug Delivery Applications
The LA-960 Particle Size Analyzer and SZ-100 Nanoparticle Analyzer may be used to measure the particle size distribution and zeta potential for drug delivery vehicles. These characteristics directly affect bioavailability, dissolution, immunotoxicity, amongst other critical formulation factors.
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The Detection of a Low Molecular Weight Enzyme Inhibitor using the OpenPlex™ system
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Determination of the Roundness of Globules in the Pharmaceutical Industry
For determination of grain size and roundness of globules, quick and objective measurement methods are required to guarantee high analytical accuracy as well as high product throughput.
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Analysis of Biopolymers with Laser Diffraction
This application note describes two experiments where laser diffraction proved capable of determining both the base biopolymer nanoparticles and also larger particles outside of the range of DLS.
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Investigating photocleavage using time‐resolved emission spectra
The choice of protecting group is of crucial importance in the success of many steps in organic synthesis and the manipulation of polyfunctional molecules, since they can prevent the formation of undesired side products and reactions.
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Characterization and mapping of active pharmaceutical ingredients and excipients in a tablet using Raman and IR spectroscopy
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Pharmaceuticals_under_humidity_controlled_atmosphere
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Char of Compounds in a pharmaceutical drug product
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Raman Microscopy in Pharmaceutical Salt Analysis
Raman Microscopy in Pharmaceutical Salt Analysis
Pharmaceutical and crystallographic samples typically require detailed characterization and analysis to optimize a samples stability, physical properties and indeed general efficacy where an active drug substance is involved.
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Determination of Particle Size and Shape of Pharmaceutical Granules
In this study, dynamic image analysis is used in the pharmaceutical industry to define the size and shape of granules created through a dry granulation process.
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Particle characterization of pharmaceutical powder mixtures
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Fluorescence on Small or Solid Samples
Samples can be valuable. Either you don’t want to waste them, or you may not have very much starting material. Biological proteins and enzymes, for example, are often obtained in small volumes and may be expensive.
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Determination of pH as Quality Control Test in Culture Media
Determination of pH as Quality Control Test in Culture Media-01
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The Detection of a Low Molecular Weight Enzyme Inhibitor using the OpenPlex™ system
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Monitoring Cell Culture Media Variability using a Simple Optical Technique (A-TEEM Molecular Fingerprinting)
Monitoring Cell Culture Media Variability using A-TEEM Spectroscopy
With the rise of protein production using mammalian cell culture, it has become increasingly important to control the quality of the cell culture media for use in production processes. Cell culture media are usually prepared as aqueous solutions and should provide everything a cell line needs for optimal cell growth as well as product yield and quality.
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Holistic Analysis of Mammalian Cell Proliferation using Fluorescence Spectroscopy
Holistic Analysis of Mammalian Cell Proliferation using Fluorescence Spectroscopy
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TPNA-500
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Automatic Total Nitrogen/Phosphorus Monitoring

Chloride ion electrode (combination) 6560S-10C
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CODA-500
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Automatic COD Monitor

Chloride ion electrode tip 7660S
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Fluoride ion electrode (combination) 6561S-10C
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NIST pH Buffer Solution Kit
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Organic Pollutant Monitor OPSA-150
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Fluoride ion electrode tip 7661S
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Ammonia electrode (combination) 5002S-10C
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LAQUA PH1300
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Benchtop Water Quality Meters

USA pH Buffer Solution Kit
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9520-10D DO electrode
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LAQUAtwin pH-33
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Ammonia electrode membrane caps
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LAQUA PH1200
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pH 1.68 Buffer Solution
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7541 DO Electrode Tip
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3551-10D Conductivity Cell (Submersible Type)
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LAQUAtwin pH-22
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Pocket Water Quality Meters

Nitrate ion electrode (combination) 6581S-10C
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LAQUA PH1100
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Benchtop Water Quality Meters

pH 4.01 Buffer Solution
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LAQUAtwin pH-11
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Pocket Water Quality Meters

Nitrate ion electrode tip 7681S
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Potassium ion electrode (combination) 6582S-10C
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LAQUA EC1100
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Benchtop Water Quality Meters

9615S-10D Standard ToupH electrode (for general laboratory application)
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pH 6.86 Buffer Solution
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9551-20D DO Electrode
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3552-10D Conductivity Cell (Submersible Type)
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Reference Electrode 2060A-10T
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Standard type

LAQUAtwin Ca-11
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Pocket Water Quality Meters

9551-100D DO Electrode
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Potassium ion electrode tip 7682S
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XGT-9000
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X-ray Analytical Microscope

Calcium ion electrode (combination) 6583S-10C
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LAQUA PC1100
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Benchtop Water Quality Meters

9618S-10D Micro ToupH electrode (for low-volume samples)
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pH 7.00 Buffer Solution
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Powder for ORP Standard Solution 160-51
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5401 DO Electrode Tip
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Reference Electrode 2565A-10T
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Double-junciton type

9300-10D ORP Electrode
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LAQUAtwin NO3-11C/NO3-11S/NO3-11
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SEC-R100 Series
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Digital Mass Flow Controller

VG Series
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Capacitance Manometer

SEC-N100 Series
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Digital Mass Flow Controller

Compact Process Gas Monitor MICROPOLE System
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Compact Process Gas Monitor

84 uS/cm Conductivity Standard Solution
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3553-10D Conductivity Cell (Submersible Type)
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100 mg/L Ammonium Ion Standard Solution
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LAQUA DS-72
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Benchtop Water Quality Meters

9680S-10D Long ToupH electrode (for large containers and long tubes)
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pH 9.18 Buffer Solution
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Powder for ORP Standard Solution 160-22
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LAQUAtwin K-11
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Pocket Water Quality Meters

pH Sensor S010
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Temperature Compensation Electrode 4163-10T
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9382-10D Conductivity Cell (Submersible Type)
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12.88 mS/cm Conductivity Standard Solution
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3561-10D Conductivity Cell (Flow Type)
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3562-10D Conductivity Cell (Flow Type)
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1000 mg/L Ammonium Ion Standard Solution
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9681S-10D Sleeve ToupH electrode (for viscous and non-aqueous samples)
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pH 10.01 Buffer Solution
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LAQUA F-74
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Benchtop Water Quality Meters

3573-10C Conductivity Cell (Flow Type)
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LAQUAtwin Na-11
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Pocket Water Quality Meters

111.8 mS/cm Conductivity Standard Solution
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Salt electrode S021
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3574-10C Conductivity Cell (Flow Type)
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pH 12.46 Buffer Solution
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LAQUA F-73
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Benchtop Water Quality Meters

Calcium ion electrode tip 7683S
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100 mg/L Calcium Ion Standard Solution
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LAQUAtwin Salt-22
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Pocket Water Quality Meters

Sodium ion electrode S022
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Partica LA-960
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Laser Scattering Particle Size Distribution Analyzer

LAQUAact PH130
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Handheld Water Quality Meters

LAQUA F-72
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Benchtop Water Quality Meters

9625-10D (for general-purpose use)
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Electrode protector cap (3 pcs/pack)
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1000 mg/L Calcium Ion Standard Solution
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LAQUAtwin Salt-11
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Pocket Water Quality Meters

Potassium Ion Sensor S030
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100 mg/L Chloride Ion Standard Solution
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1000 mg/L Chloride Ion Standard Solution
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LAQUAact PH120
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Handheld Water Quality Meters

9630-10D (for low conductivity samples)
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LAQUAtwin EC-33
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Pocket Water Quality Meters

Nitrate ion electrode S040
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100 mg/L Fluoride Ion Standard Solution
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LAQUAact PH110
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Handheld Water Quality Meters

9631-10D (for hydrofluoric acid or HF samples)
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Printer (for GLP/GMP compliance)
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Cyanide ion electrode 8001-10C
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LAQUAtwin EC-22
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Pocket Water Quality Meters

Calcium Ion Sensor S050
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1000 mg/L Fluoride Ion Standard Solution
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LAQUAact EC120
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Handheld Water Quality Meters

9632-10D (for strong alkali samples)
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Chloride ion electrode 8002-10C
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LAQUAtwin EC-11
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Pocket Water Quality Meters

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LAQUAact EC110
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Handheld Water Quality Meters

6367-10D (for high accuracy pH measurement)
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Sulfide ion electrode 8003-10C
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100 mg/L Nitrate Ion Standard Solution
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[Exclusively for TWIN] Conductivity Cell 0413
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PSA300
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Static Image Analysis System Particle Size

Digital simulator X-51
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Digital simulator X-52
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USB cable
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AC adapter cable set
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LAQUAact DO120
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Handheld Water Quality Meters

LCD protection sheet
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6377-10D (for low-conductivity samples and non-aqueous solvents)
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Iodide ion electrode 8004-10C
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1000 mg/L Nitrate Ion Standard Solution
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[Exclusively for CARDY] Sodium ion electrode 0221
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For the C-121 and C-122

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Ammonia Ionic Strength Adjustor
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Calcium Ionic Strength Adjustor
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Chloride Ionic Strength Adjustor
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LAQUAact DO110
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Handheld Water Quality Meters

Protection cover
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Bromide ion electrode 8005-10C
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6252-10D (for food samples)
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More Condensed pH Standard Solution 110-4
Fluoride Ionic Strength Adjustor
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Nitrate Ionic Strength Adjustor
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Potassium Ionic Strength Adjustor
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Ammonia Electrode Filling Solution
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Calcium Electrode Filling Solution
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Chloride Electrode Filling Solution
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LAQUAact PD110
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Handheld Water Quality Meters

Electrode hook for D-70 Series, ES-71, and OM-71
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0040-10D ISFET pH electrode
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Copper ion electrode 8006-10C
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LAQUAact PC110
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Handheld Water Quality Meters

Cadmium ion electrode 8007-10C
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Glass Electrode 1066A-10C
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Standard type

Glass Electrode 1076A-10C
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For measurement of low-conductivity water and non-aqueous solvents.

FA-70A Integrated Electrode Stand
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6069-10C (for very slender test tubes)
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Powder for pH Standard Solution 150-4
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Lead ion electrode 8008-10C
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6261-10C (for flat surface measurement)
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FA-70S Electrode stand (adjustable type)
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Thiocyanate ion electrode 8009-10C
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DP-50S Electrode stand
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Fluoride ion electrode 8010-10C
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ICP-NEO Software HORIBA
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ICP Software

XGT-7200
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X-ray Analytical Microscope

MESA-50K
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X-Ray Fluorescence Analyzer

MESA-50
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X-Ray Fluorescence Analyzer

Ultima
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Ultra Fast TCSPC Lifetime Fluorometer

SpectraLED
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LED Phosphorescence Light Sources

OpenPleX
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Manual label-free molecular interaction analysis machine Flexible Research Platform

XelPleX
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Fully automated label-free molecular interaction analysis machine One System for Molecule Screening & Crude Sample Analysis

Fluorolog
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Steady State and Lifetime Modular Spectrofluorometer

DeltaTime
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TCSPC Lifetime Kit

DeltaPro
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TCSPC Lifetime Fluorometer

DeltaFlex
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TCSPC Lifetime Fluorometer

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Inverted Raman Microscope

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Raman Spectrometer - Confocal Raman Microscope

Aqualog
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Water Treatment Plant Analyzer

LabRAM HR Evolution
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Confocal Raman Microscope

Water Quality Meter with HART communication HQ-300
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Industrial residual ch analyzer HR-200 (Four-Wire Analyzer)
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HE-300C
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Industrial electric conductivity meter (Two-Wire Transmitter)

HP-300
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Industrial pH meter (Two-Wire Transmitter)

HE-200C
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Industrial electric conductivity meter (Four-Wire Analyzer)

HP-200
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Industrial pH meter (Four-Wire Analyzer)

Industrial residual chlorine meter HR-480 (The Slim48 series)
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HE-480C
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Industrial conductivity meter (low concentration type)

Industrial pH meter four-point alarm and a time sharing proportional control HP-960FTP
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HP-480TP
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Industrial pH meter - Industrial time sharing proportional control

Industrial pH meter - Pulse poportional control HP-480PL
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Industrial pH meter HP-480
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HE-300R
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Industrial electric resistivity meter (Two-Wire Transmitter)

HE-200R
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Industrial electric resistivity meter (Four-Wire Analyzer)

HE-960HI
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Sanitary Conductivity Meter (Wide-range type)

HT-110
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Pharmaceutical Total Organic Carbon Monitor - Online TOC-Analyzer

HE-960RW
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Industrial resistivity meter

Industrial resistivity meter HE-480R
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Sanitary Conductivity Sensor (Ferrule Clamp type) FES-210L
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Insertion sensor type for wide-range conductivity meter HE-960HI

FES-310L
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Sanitary Conductivity Sensor (Flow Through type)

ESH-01-C-SN
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Sanitary Conductivity Sensor (Ferrule Clamp type) for Low Concentrations

FS-01FC-SL Series
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Sanitary Conductivity Sensor (Flow Through type) for Low Concentrations

HE-960CW
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2-channel Sanitary Conductivity Meter (Low Concentration type)

CAMSIZER P4*
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Dynamic Image Analysis System Particle Size