Applications

TERS Characterization of phospholipid bilayers and detection of nanoparticles

Non-destructive and label-free hyperspectral chemical imaging of phospholipid bilayers with spatial resolution of 7 nm

TERS Characterization of phospholipid bilayers and detection of nanoparticles

Phospholipid bilayers, major constituents of membranes act as a barrier of selective permeability for the nanoparticles now largely into our environment. Studying the interactions between nanoparticles and cellular membranes requires a molecular chemical probe with nanometer resolution capability.

This application reports on TERS characterization of binary phospholipid bilayer systems deposited onto a gold coated coverslip.  Such samples are used as model samples for directly and chemo-selectively visualizing the distribution of a lipid constituent at the nanometer scale. In addition, nanomaterials have been introduced to mimic the interactions between nanoparticles and cellular membranes and better understand their toxicity on human health. The sensitivity of TERS for the detection and identification of NPs in phospholipid bilayers is demonstrated down to femtomolar concentration with a spatial resolution down to 7 nm. A specific liquid cell has also been developed to permit TERS measurements in solution and results of graphene oxide containing samples are presented.

Related Products

XploRA Nano
more XploRA Nano

AFM-Raman for Physical and Chemical imaging

LabRAM Nano
more LabRAM Nano

AFM-Raman for physical and chemical imaging

OmegaScope
more OmegaScope

The AFM optical platform

LabRAM Soleil Nano
more LabRAM Soleil Nano

Real-time and Direct Correlative Nanoscopy

Request for Information

Do you have any questions or requests? Use this form to contact our specialists.

Corporate