Biopharma and Pharma

创新治疗模式

创新治疗模式能够靶向传统药物无法触及的致病通路，为癌症、神经退行性疾病和遗传性疾病等难治性病症开辟了新的治疗途径。许多创新治疗模式专为靶向病变细胞或组织设计，最大限度地减少脱靶效应，提高治疗的整体安全性和耐受性。创新治疗模式通常通过独特的作用机制发挥作用，能够克服传统药物可能产生的耐药通路。部分创新治疗模式可根据患者的个体基因构成或疾病特征进行定制，提供更加个性化的治疗方案。创新治疗模式常采用新型递送系统，可将治疗有效载荷直接送达作用部位，从而提高药物疗效并减少副作用。

生物制剂、腺相关病毒（AAVs）和外囊泡都是目前正在研究的创新治疗模式，HORIBA 凭借其独特的拉曼光谱、荧光光谱、颗粒分析技术和微生物检测综合解决方案，为这些研究提供支持。

应用

产品

在线讲座

视频

浏览应用文档

TERS Characterization of phospholipid bilayers and detection of nanoparticles

本篇应用文档报道了 TERS 表征沉积在镀金衬底上的磷脂双分子层，该样品可以用作标准样品，检测到脂质成分在纳米尺度上的分布。此外，还引入了纳米材料来模拟纳米颗粒和细胞膜之间的相互作用，帮助更好地研究纳米材料对人类健康的毒性。 TERS 检测磷脂双分子层中纳米颗粒的灵敏度可以低至飞摩尔浓度，空间分辨率低至 7 nm。还开发了一种特定的液体样品池，可以实现在溶液中进行 TERS 测量，应用文档中提供了测试氧化石墨烯样品的结果。

The complexity of viral particles remains one of the biggest hurdles in the development process. In this note, the upstream process of analyzing viral preparations is addressed, as well as the use of multi-laser nanoparticle tracking analysis (NTA) as a cost and time efficient method to measure size, count virus particles, and correlate to infectious titer.

Nanoparticles used for drug delivery is an important research field combining the life sciences with nanotechnology. While the strict definition of a nanoparticle is between 1 – 100 nm, we can extend the upper size range in the context of this application up to approximately 500 nm. Laser diffraction provides the advantage of being able to measure larger particles.

Considerable research has been conducted exploring the use of nanoparticles composed of biopolymers as a drug delivery vehicle. Much of the particle size analysis in this field has been done using dynamic light scattering (DLS). However, certain materials will feature larger particles that are outside the upper size range of DLS, but within the capability of laser diffraction.

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HORIBA 解决方案

PoliSpectra RPR

PoliSpectra RPR

高通量拉曼快速筛选平台

XploRA™ PLUS

高性能全自动拉曼光谱

Veloci 生物制药荧光分析仪

Veloci 生物制药荧光分析仪

A-TEEM™ 光谱技术

Aqualog-A-TEEM 工业 QC/QA 分析仪

Aqualog-A-TEEM 工业 QC/QA 分析仪

一种简单、快速、“无栏”的分子指纹技术

Duetta

荧光及吸收光谱仪

ViewSizer 3000 纳米颗粒追踪分析仪

ViewSizer 3000 纳米颗粒追踪分析仪

多激光 NTA 技术开创者

Partica LA-960V2

Partica LA-960V2

激光粒度分析仪

Partica mini LA-350

Partica mini LA-350

激光粒度分析仪

nanoPartica SZ-100V2

nanoPartica SZ-100V2

纳米粒度及Zeta电位分析仪

MacroRAM™

台式拉曼光谱仪

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观看在线讲座和视频

Using Veloci with HORIBA's A-TEEM technology, enables precise characterization of culture media conditions during cell proliferation.

The A-TEEM Compliance Package is now available from HORIBA and enables A-TEEM to be used in a GMP environment. Discussion points will be around both the pharmaceutical applications of A-TEEM and the details of the compliance package for GMP labs.

The webinar will be an overview of the A-TEEM technique and some specific applications for which information is gained relevant to pharmaceutical development and process analysis. Addressing such applications requires a set of tools for A-TEEM spectroscopy to help adopt the technique into labs that require Good Manufacturing Practices (GMP) and are also focused on efficiency and ease-of-use.

Join Dr. Kevin Dahl of Particlese LLC and Dr. Linda Kidder of HORIBA Scientific provide tips and alternative solutions for better vaccine development and quality. They will discuss the application of multi-laser nanoparticle analysis (NTA) in determining vaccine degradation and total particle count. They will also present a new analytical approach, fluorescence A-TEEM method for rapid screening of similar but different vaccine final formulations.

Quantitative imaging techniques, such as FRET-FLIM, FCS and FCCS, and RICS are powerful tools to monitor the dynamics and interactions of proteins in live cells.

The need for fluorescent bioprobes has exploded in the last decades in the Life Sciences and Medical domains for applications such as bioimaging, lab-on-chip diagnostics, drug development or cell sorting.

The large variety of fluorescent probes, such as organic dyes, biological biotags and fluorescent nanostructures, are intensively studied due to their inherent suitability for a wide range of life science applications. Thanks to the complementary nature of its analytical solutions, HORIBA's unique offer covers fluorescence, particle analysis, AFM, Raman and XRF characterization techniques, helping to gain valuable insight into optical properties, size, morphology and composition of your bioprobes.

New camera, new imaging, new FLIM

自动进行批量样品成分检测，适用于水环境、酒类、药品等领域的QC/QA，用于复杂多组份成分分析检测——Fast-01自动取样器，专用于Aqualog 同步吸收-三维荧光(A–TEEM)光谱仪，测试速度快、精度高、数据质量好。

A-TEEM™ stands for simultaneous Absorbance, Transmission, and Fluorescence Excitation-Emission-Matrix (EEMs) Acquisition.

Byron Purse on his work modifying Fluorescence of DNA & RNA

The simple and ideal excitation sources for TCSPC

EzSpec Software for Duetta and its winning user experience

Money down on this Head 2 Head EEM acquisition comparison

A-TEEM acquires chemical ID with fluorescence spectroscopy

Automatically discover Fluorescence profiles in about 60 seconds

EzSpec and its apps, making research too EZ

One of those things that make EzSpec so good

Automatically discover Fluorescence profiles in about 60 seconds

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