Fluorescent Bioprobes

Fluorescent Bioprobes Publications

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Discover how our instruments are helping researchers worldwide in bringing answers for their problematics during fluorescent bioprobes investigation.

Enhanced Emission of Zinc Nitride Colloidal Nanoparticles with Organic Dyes for Optical Sensors and Imaging Application

Discover how the HORIBA fluorescence and Raman instruments enabled a full characterization of zinc nitride colloidal nanoparticles (Zn3N2) with organic Dyes. To improve their performance in imaging, optical and structural properties of the colloidal nanoparticles were tuned. Aqualog was used to obtain the excitation emission matrix , Fluoromax-2 to sudy the luminesence and Fluorolog to measure the Lifetime of synthesized. The bonding configuration as well as the presence of functional groups in the colloidal solution was determined using Raman spectrometer LabRam HR 800

Directionality of light absorption and emission in representative fluorescent proteins

One aspect of fluorescent proteins (FP) that has remained largely neglected is the directionality of their optical properties, characterized by vectors: the excitation and emission transition dipole moment (xTDM and mTDM), respectively. In the present work, determination of the directionality of light absorption and emission in several commonly used fluorescent proteins is described. Thanks to the HORIBA FluoroMax4 fluorometer equipped with calcite polarizer-based fluorescence polarization module, it was possible to carry out disambiguation of mTDM determination through measurements of fluorescence anisotropy (FA) of FP solutions.

Luminescent chitosan/carbon dots as an effective nano-drug carrier for neurodegenerative diseases

One of the limitations of drug delivery in neurodegenerative diseases is the impermeability of blood brain barrier. To overcome this limitation, Prof. Stephen and his team synthesized chitosan/carbon dot matrix where the dopamine was encapsulated to form a dopamine nanocomposite. To fully investigate the properties of carbon dots, three HORIBA systems were used: LabRAM HR to confirm the carbonization of Chitosan, FluoroLog-3 to determine the emission properties of the Carbon Dots, and the SZ-100 instrument to validate the size of the CD and Dopamine nanocomposite through Dynamic Light Scattering.

Single-molecule visualization of DNA G-quadruplex formation in live cells

The formation of four-stranded DNA has been tracked in living human cells, allowing scientists to see how it works, and its possible role in cancer. A collaboration between Cambridge and Leeds universities enables to visualize for the first time this structure in living cells thanks to the design of a specific fluorescent bioprobe. The Duetta was used during the synthesis process to measure the fluorescence profile of DNA depending on the concentration of the fluorescent probe in order to define the dose that will guaranty minimum interference with their structure and dynamics.

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