药物开发与制剂

We introduce EDXRF analysis as a rapid and reliable method for Zinc determination in liquid solution. We demonstrated Zn determination at ppm levels using the calibration curve method with commercial Zinc liquid standard samples. Our calibration curve had a good linearity (R2 > 0.999) and we could accurately determine 22 ppm of Zn in 1 minute. The results demonstrated that EDXRF is an effective tool for rapid and reliable laboratory analysis.

本篇应用文档报道了 TERS 表征沉积在镀金衬底上的磷脂双分子层，该样品可以用作标准样品，检测到脂质成分在纳米尺度上的分布。此外，还引入了纳米材料来模拟纳米颗粒和细胞膜之间的相互作用，帮助更好地研究纳米材料对人类健康的毒性。 TERS 检测磷脂双分子层中纳米颗粒的灵敏度可以低至飞摩尔浓度，空间分辨率低至 7 nm。还开发了一种特定的液体样品池，可以实现在溶液中进行 TERS 测量，应用文档中提供了测试氧化石墨烯样品的结果。

The use of low molecular weight molecules in the industries of drug discovery and agri-food has become increasingly important over the course of a century of drug research and science development in agriculture and in pharmaceutical field.

This application highlights the development of an oligosaccharide chip (surface functionalization, density of immobilization, spacer arm length) on the same SPRi platform using conductive polymers. These results are highlighted through the example of interactions between HS and SDF-1 α chemokine.

HORIBA provides the pharmaceutical industry, biotech companies and academic research laboratories with high performance instrumentation based on SPRi technology (Surface Plasmon Resonance imaging). To demonstrate the power of this technology, we carried out an experiment based on an antibody-antigen interaction. Original surface chemistry combined with an electrochemical process allows the rapid coupling of biomolecules to the gold layer (polypyrrole co-polymerisation) on the top of a glass prism.

腺相关病毒(AAV)作为递送细胞与基因疗法及疫苗的病毒载体正得到广泛应用。随着生产规模扩大以满足日益增长的需求，我们需要更快获取更多信息。

Nanoparticles used for drug delivery is an important research field combining the life sciences with nanotechnology. While the strict definition of a nanoparticle is between 1 – 100 nm, we can extend the upper size range in the context of this application up to approximately 500 nm. Laser diffraction provides the advantage of being able to measure larger particles.

Considerable research has been conducted exploring the use of nanoparticles composed of biopolymers as a drug delivery vehicle. Much of the particle size analysis in this field has been done using dynamic light scattering (DLS). However, certain materials will feature larger particles that are outside the upper size range of DLS, but within the capability of laser diffraction.