During pharmaceutical and cosmetic formulation process, an important step is in the control of the distribution of the compounds once the product is designed in its final state. For example, in a pharmaceutical tablet, the size and distribution controls over a large area of the tablet are important for drug release control. That can be also applied on liquid products, like a nasal spray or oral suspensions. It also concerns the emulsions and creams commonly proposed by cosmetic companies. In that case, the point of interest is in the analysis of the distribution of the compounds after the application of the cream. In order to simulate skin, cosmetic manufacturers commonly use some rough PMMA slides.
This step in the control process is required so a technique is able to chemically characterize the product as they are, in a non-invasive and non-destructive manner. Thus, vibrational spectroscopies are well designed for such characterization. Moreover, confocal Raman microscopy is the perfect tool for this.
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