Biotechnology

What is Biotechnology?

Biotechnology is a major branch of life sciences that focuses on manipulating living organism and biological systems with the intent to create or modify products for specific use. Biotechnology uses a broad range of biology discipline such as genetics, biochemistry, molecular biology and so on. Biotechnology is used across a diversified range of applications, including medicine, agriculture, industrial, and environmental.

HORIBA offers a large choice of innovative technologies such as steady state and lifetime fluorescence, X-Ray fluorescence, particle size analysis and Zeta potential analysis to support a wide range of biotechnology applications.

Browse Applications

Quantitative Analysis of Low-concentration Hydrogen Content in Titanium Alloy
Can we perform quantitative analysis of hydrogen in a titanium alloy to prevent hydrogen embrittlement?
Production of a single domain antibody Q17c directed against recombinant HER2 protein and its binding study by Surface Plasmon Resonance imaging technology
Production of a single domain antibody Q17c directed against recombinant HER2 protein and its binding study by Surface Plasmon Resonance imaging technology
This application note shows how binding kinetics of single-domain antibodies can be studied with SPRi technology. QVQ produces single-domain antibodies from camelids (sdAbs or VHH). Like conventional Abs, sdAbs are able to bind specific epitopes with high binding affinity. The small size of sdAbs allows for enhanced tumor penetration and fast blood clearance, features that are favorable for in vivo imaging applications. Here, the binding of the anti-HER2 sdAb Q17c to recombinant HER2 protein was assessed using Surface Plasmon Resonance imaging (SPRi). An optimization of immobilization conditions was performed for Q17c and its specific antigen HER2 using a single SPRi-Biochip.
Elemental micro-analysis of leaves using EDXRF
Calcium micro-nodules are identified within mulberry leaves, and XRF mapped imaging provides a correlation between nodule concentration and leaf age. In a seperate study, the uptake of heavy element pollutants by plants is investigated, with high resolution images quickly acquired to show the distribution of lead through the leaf.
Biological applications of XRF microscopy
The effect of zinc on gastric ulcer healing has been investigated - mapped imaging of tissue samples shows evidence of zinc accumulation within the ulcerated tissue. In a separate study a fish otolith ('ear bone') has been analysed to reveal its heterogeneous elemental composition and physical structure.
High Throughput Screening of Affimer Proteins using SPRi Label-Free Technology
Monitoring Whole Leaf Fluorescence Using Time‐resolved Techniques
Light incident on a leaf can be absorbed by chlorophyll to commence the photosynthetic cycle. Excess energy can be liberated as heat or by emission of fluorescence and this can be used to assess the efficiency of the photosynthetic process.
Stopped flow time‐resolved fluorescence study of serum albumin – curcuminoid binding
Rapid mixing accessories to perform stopped flow measurements have found application in characterizing interactions and reactions occurring in solution. Reactants are expelled from syringes, mixed and injected into a flowcell.
Dye‐protein binding monitored in a microliter volume using timeresolved fluorescence
The potential health benefits stemming from the antioxidant activity of curcumin, commonly found in turmeric (Curcuma longa L), has attracted the interest of several research groups.
Analytical Chemistry in Biotechnology

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For measurement of low-conductivity water and non-aqueous solvents.

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Converter for peracetic acid monitor

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HT-110
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Pharmaceutical Total Organic Carbon Monitor - Online TOC-Analyzer

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HE-480R
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Insertion sensor type for wide-range conductivity meter HE-960HI

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ESH-01-C-SN
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FS-01FC-SL Series
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Sanitary Conductivity Sensor (Flow Through type) for Low Concentrations