Biotechnology

What is Biotechnology?

Biotechnology is a major branch of life sciences that focuses on manipulating living organism and biological systems with the intent to create or modify products for specific use. Biotechnology uses a broad range of biology discipline such as genetics, biochemistry, molecular biology and so on. Biotechnology is used across a diversified range of applications, including medicine, agriculture, industrial, and environmental.

HORIBA offers a large choice of innovative technologies such as steady state and lifetime fluorescence, X-Ray fluorescence, particle size analysis and Zeta potential analysis to support a wide range of biotechnology applications.

Browse Applications

Production of a single domain antibody Q17c directed against recombinant HER2 protein and its binding study by Surface Plasmon Resonance imaging technology
Production of a single domain antibody Q17c directed against recombinant HER2 protein and its binding study by Surface Plasmon Resonance imaging technology
This application note shows how binding kinetics of single-domain antibodies can be studied with SPRi technology. QVQ produces single-domain antibodies from camelids (sdAbs or VHH). Like conventional Abs, sdAbs are able to bind specific epitopes with high binding affinity. The small size of sdAbs allows for enhanced tumor penetration and fast blood clearance, features that are favorable for in vivo imaging applications. Here, the binding of the anti-HER2 sdAb Q17c to recombinant HER2 protein was assessed using Surface Plasmon Resonance imaging (SPRi). An optimization of immobilization conditions was performed for Q17c and its specific antigen HER2 using a single SPRi-Biochip.
Elemental micro-analysis of leaves using EDXRF
X-ray fluorescence (XRF) provides fast characterisation of sample element composition down to parts per million (ppm) levels – however, biologists often ignore this useful technique because it traditionally requires destructive vacuum conditions. Bio-samples containing large amounts of water will quickly dehydrate under these conditions. With the groundbreaking XGT-5000, though, these concerns are removed. Samples are analysed at normal atmospheric pressure, so that the resulting qualitative/quantitative data truly represents a healthy sample. In this application note the unique 10 µm spatial resolution of the XGT-5000 coupled with atmospheric pressure analysis allows leaf structure and behaviour to be explored. By using a combination of single point analysis and mapped imaging it is possible to learn more about the growth of leaves, and their behaviour in the presence of pollutants.
Biological applications of XRF microscopy
X-ray fluorescence (XRF) micro-analysis provides the research with a fast and non-destructive means of measuring elemental composition on a microscopic scale. However, it has long been a drawback of the technique that analysis must be carried out under vacuum conditions. Whilst for many applications this presents no problem other than inconvenience and time, within biological fields it means that many desired experiments are simply not possible. The vacuum conditions will quickly dehydrate and damage the typical water containing samples (leaves, micro-organisms, tissue, cells etc) key to biological/medical research. However, the unique x-ray guide tube technology of the XGT-5000 now allows high spatial resolution analysis for all elements from sodium (Na) to uranium (U) at atmospheric pressure – hence, hydrated samples, fine powders, and even liquids, can now be safely analysed for composition (quantitative and qualitative) and element distribution.
High Throughput Screening of Affimer Proteins using SPRi Label-Free Technology
Monitoring Whole Leaf Fluorescence Using Time‐resolved Techniques
Light incident on a leaf can be absorbed by chlorophyll to commence the photosynthetic cycle. Excess energy can be liberated as heat or by emission of fluorescence and this can be used to assess the efficiency of the photosynthetic process.
Stopped flow time‐resolved fluorescence study of serum albumin – curcuminoid binding
Rapid mixing accessories to perform stopped flow measurements have found application in characterizing interactions and reactions occurring in solution. Reactants are expelled from syringes, mixed and injected into a flowcell.
Dye‐protein binding monitored in a microliter volume using timeresolved fluorescence
The potential health benefits stemming from the antioxidant activity of curcumin, commonly found in turmeric (Curcuma longa L), has attracted the interest of several research groups.
Analytical Chemistry in Biotechnology

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