Veloci BioPharma Analyzer

A-TEEM Spectroscopy

The Veloci A-TEEM BioPharma Analyzer contains innovative, column-free molecular fingerprinting technology designed for the biopharma and pharma industries. By integrating the selectivity of chromatography with the benefits of optical spectroscopy, Veloci offers a fast, simple, and cost-effective method for comprehensive component analysis in various industrial QC/QA life science applications. Unlike traditional methods such as chromatography and mass spectrometry, Veloci’s A-TEEM™ Molecular Fingerprinting technology provides component analysis without time consuming and slow separations. This allows simplified workflows and drastically reduces ownership costs. This versatile tool requires no sample preparation and is suitable for a wide range of applications, including monoclonal antibody discrimination, cell media monitoring, vaccine characterization, protein stability analysis, and AAV quantification. The Veloci A-TEEM BioPharma Analyzer enables label-free intrinsic fluorescence analysis, offering high accuracy and efficiency in research, production and QC/QA environments.

事业部: 科学仪器

产品分类: 荧光光谱仪

制造商: HORIBA Scientific

Key Benefits

Selectivity of chromatography, but using spectroscopy.
Superior sensitivity compared to HPLC/MS and other spectroscopic techniques like absorbance, FTIR, and Raman.
Hassle-free operation with no columns, mobile phase, or sample preparation needed. The lack of a mobile phase drastically reduces solvent usage and eliminates the cost of proper disposal.
Cost-effective and user-friendly: Suitable for both research labs and production processes

Applications

Monoclonal Antibodies (mAb)
AAVs (Adeno-Associated Viruses)
Vaccines
Protein Stability and Aggregation
Antibody-Drug Conjugates
Cell Media Monitoring and Bioreactor Monitoring
Exosomes

EzSpec Software

EzSpec allows users to see recent methods and data, as well as personal favorites. Click here for more on EzSpec.

Product Video

Download the Veloci BioPharma Analyzer brochure to learn more

Veloci Biopharma Analyzer
Detection Limit	Parts per billion (sample and wavelength dependent)
Excitation/Absorbance Wavelength Range	200 to 800 nm
Fluorescence Emission Wavelength Range	250 to 800 nm
Wavelength Accuracy	+/- 1 nm
EEM/A-TEEM Acquisition Rate	As fast as 60 seconds (sample and wavelength dependent)
Optional Accessories	Remote fiber optic probe, Autosampler with flow cell
Minimum Sample Volume	70 microliters
Sample Handling, Internal	Cuvette and solid sample holders
Sample Handling, External	Autosampler (96 sample maximum)
Light Source	Xenon arc lamp
Validation	Complies with US Pharmacopia
Dimensions (W x D x H)	24 in x 17 in x 13 in; 618 mm x 435 mm x 336 mm
Weight	32.72 kg (72 lbs.)

Characterizing Monoclonal Antibody Purification with 2D Fluorescence Spectroscopy

Fluorescence spectroscopy is widely used in various industries, including life sciences. Two-dimensional (2D) fluorescence excitation-emission matrix (EEM) spectroscopy has been utilized for over 30 years to characterize or “fingerprint” biological samples.

详情

随着利用哺乳动物细胞培养生产蛋白质的兴起，在生产过程中控制细胞培养基的质量变得越来越重要。用于生物反应器的细胞培养基通常为水溶液，并提供细胞最优生长所需的一切物质。

详情

监测培养基的条件对促进再生药物和蛋白质合成等过程中的细胞增殖非常重要。由于培养基介质组份复杂，且荧光成份多样，因此需要荧光激发发射三维矩阵(EEM)来同时全面展现发光信息。本篇报告主要通过测量EEM来监测细胞增殖过程中的细胞培养基组份的变化。

详情

众所周知，胰岛素是一种由胰腺产生的蛋白质激素，是基本代谢过程中所必需的激素。对于胰岛素的稳定性和聚集性等性能检测显得尤为重要，已有文献报道了通过荧光激发发射矩阵(EEMs)和紫外-可见吸收光谱（UV-Vis）来研究。[1]目前，商业治疗胰岛素主要分为两类: 速效胰岛素和长效胰岛素。相比于长效胰岛素，速效胰岛素在蛋白质序列中只有1到3个残基。

A-TEEM Direktor Brochure