Lyufei Chen

Biography

Lyufei Chen is an accomplished application scientist at HORIBA, specializing in A-TEEM fluorescence spectroscopy. Originally from the small village of Zhuzhou in Hunan Province, China, she developed a deep interest in science early on. She earned her Ph.D. in Materials Science and Chemical Engineering from Stony Brook University on Long Island, New York, where she studied nanomaterials and expanded her expertise at the Center for Functional Nanomaterials at Brookhaven National Laboratory. With extensive experience in method development and validation in the pharmaceutical industry, Lyufei now focuses on A-TEEM molecular fingerprinting. She works closely with clients in the biopharma and pharmaceutical sectors, addressing technical challenges and providing innovative solutions using A-TEEM technology.

Articles by Lyufei Chen

The biopharmaceutical industry is currently shifting from reactive, offline quality control measures to a proactive quality by design (QbD) framework, facilitated by Process Analytical Technology (PAT). By employing rapid, non-destructive spectroscopy, manufacturers can monitor processes continuously.

A-TEEM (Absorbance-Transmittance Excitation-Emission Matrix) is a multi-dimensional analytical technique that identifies cell culture media variability that Raman, LC-MS, and 2D-Fluorescence miss. By providing a quantitative 'molecular fingerprint' in seconds, A-TEEM prevents batch failures, ensures GMP regulatory compliance, and reduces QC costs.

In the BioPharm International article, "Extracellular Vesicles and Fluorescence Excitation-Emission Matrix Spectroscopy," author Lyufei Chen explores the growing significance of extracellular vesicles (EVs) as vital intercellular messengers in health and disease.

Other Resources by Author Lyufei Chen

Pham TTP, Ro KS, Chen L, Mahajan D, et al. Microwave-assisted dry reforming of methane for syngas production: a review. Environ Chem Lett. 2020.

Chen L, Sharma S, Darienzo RE, et al. Decoration of cellulose nanocrystals with iron oxide nanoparticles. Mater Res Express. 2020.

Godbole A, Chen L, Desai J, Raghava S, et al. Implementation of innovative process analytical technologies to characterize critical quality attributes of co-formulated monoclonal antibody products. Biotechnol Bioeng. 2025.

Chen L, Costa E, Kileti P, Tannenbaum R, Lindberg J, et al. Sonochemical synthesis of silica-supported iron oxide nanostructures and their application as catalysts in Fischer–Tropsch synthesis. Micro. 2022.

Pham Minh D, Roger AC, Parkhomenko K, et al. Selective hydrogenation of carbon dioxide into methanol. In: Conversion of Carbon Dioxide. Springer; 2019.

Chen L. Spectroscopic PAT for real-time molecular fingerprinting: at HORIBA process analytical technology-based quality assessments accelerate biopharmaceutical...Genet Eng Biotechnol News. 2026.

Gilmore A, Chen L. Is my wine red enough?Chem Aust. 2024.

Chen L. Synthesis, characterization and catalytic applications of supported iron oxide nanostructures. 2019.

Chen L, Sharma S, Darienzo R, Tannenbaum R. Decoration of cellulose nanowhiskers with iron oxide nanoparticles. ChemRxiv. 2018.

Chen L, Costa E, Mahajan D. Minimizing CO2 production during syngas catalysis mediated by nano-sized iron supported on silica spheres. Paper presented at: 2019 Spring Meeting; 2019.

Chen L, Tannenbaum R, et al. Synthesis of cellulose nanowhiskers tethered with iron oxide nanoparticles. Am Chem Soc. 2017.

Sharma S, Chen L, Pham V, et al. Metal nanoparticle decorated meso-graphene oxide composites as theranostics. Am Chem Soc. 2017.

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