Small molecule therapeutics are very flexible, with a variety of administrations routes, from pills, capsules, to inhalation devices. The quality of many of these products depends on knowing how much of a component is present, how it is distributed, and what size it is. HORIBA has a portfolio of analytical instruments that address these questions, with a full range of particles sizing techniques, to best-in-class Raman microscopy. This portfolio of products speeds up product development, answers critical questions for troubleshooting, and is indispensable for contaminant identification.

Browse Applications

Rapid Particle Size Analysis of Topical Ophthalmic Formulations
Drug particle size and distribution are key critical quality attributes that govern stability, ocular retention via solution thickness, and therapeutic release characteristics. The laser diffraction technique is an elegant method used to establish the fundamentals of ophthalmic formulations prior to pharmacokinetic or clinical studies. To fulfill the requirements set out by the FDA, our recommendation is the Partica LA-960V2 Particle Size Analyzer.
Real-Time Prediction of Polymer-Coated Multiparticulate Dissolution using Process Analytical Technology
Process Analytical Technology, or “PAT” is the term given to analytical instruments developed to measure certain attributes of product within the manufacturing process, eliminating, or substantially minimizing the need for sampling for off-line analysis. This approach offers process measurements in-situ with instant access to data, which facilitates rapid decisions during product development and manufacture.
Raman spectra of DayQuil™ and NyQuil™ collected with an immersion probe fiber-coupled to the MacroRAM™ Raman spectrometer, and a picture of the immersion probe setup.
Quantitative Analysis Using Raman Spectroscopy in Pharmaceutical Applications
Raman spectroscopy is well known as a powerful analytical method for qualitative chemical analysis. Less well known is that under certain conditions Raman spectroscopy can also be an effective method for quantitative analysis. Here we demonstrate that capability for quantitative analysis under a variety of conditions, involving different solutes in a solution and solution mixtures, and its applications to pharmaceutical analysis such as content uniformity.
Guide to D-values in Pharmaceutical Particle Characterization
It is necessary to have a particle size quantification system better suited to the specific requirements of the pharmaceutical industry; and D-values, while basic, fit this requirement well.

 ↑ Back to Top