SPRi-Arrayer

SPRi Arrayer

Direct contact spotting

SPRi-Arrayer is an automatic, compact and portable apparatus. It prints DNA, oligonucleotides, proteins, bacterial clones and other materials with low cross contamination using Xtend metal-ceramic capillary pins. SPRi-Arrayer includes microarray design software and is integrated with microarray image processing and data analysis tools.

 

 

Segment: Scientific
Division: Molecular and Microanalysis
Base product

Benchtop SPRi-Arrayer for printing microarrays of biological samples on glass, gold surfaces, or on membrane substrates.

  • Easy to start
  • Fast and versatile
  • Prints onto SPRi-Biochip™, SPRi-Slides or any other standard slides
  • Prints up to 400 (20x20) samples on SPRi-Slides or SPRi-Biochip™
  • Spot size : from 140 to 500 µm, depending on matrix size

Arrayer SPRi

  • Print Method: Contact printing
  • Number of printing needles: 1-16 in various patterns
  • Slide capacity: 14 slides
  • SPRi-Biochip™ capacity: 8 biochips
  • SPRi-Slide capacity: 8 slides
  • Slide locks: Independent unit
  • Needle cleaning technology: Fluid stream washing, vacuum drying
Production of a single domain antibody Q17c directed against recombinant HER2 protein and its binding study by Surface Plasmon Resonance imaging technology
Production of a single domain antibody Q17c directed against recombinant HER2 protein and its binding study by Surface Plasmon Resonance imaging technology
This application note shows how binding kinetics of single-domain antibodies can be studied with SPRi technology. QVQ produces single-domain antibodies from camelids (sdAbs or VHH). Like conventional Abs, sdAbs are able to bind specific epitopes with high binding affinity. The small size of sdAbs allows for enhanced tumor penetration and fast blood clearance, features that are favorable for in vivo imaging applications. Here, the binding of the anti-HER2 sdAb Q17c to recombinant HER2 protein was assessed using Surface Plasmon Resonance imaging (SPRi). An optimization of immobilization conditions was performed for Q17c and its specific antigen HER2 using a single SPRi-Biochip.
Production of a rescued recombinant monoclonal antibody directed against a steroid hormone and its binding study thanks to Surface Plasmon Resonance imaging technology
Production of a rescued recombinant monoclonal antibody directed against a steroid hormone and its binding study thanks to Surface Plasmon Resonance imaging technology
A monoclonal antibody (mAb) highly specific to a steroid hormone (undisclosed) of 290 Daltons was analyzed thanks to SPRi technology. This application note highlights the sensitivity of the XelPleXTM system for the detection of small molecules.
Streamlined SPRi-MS coupling to detect and identify a kinase in Cell lysate using the DARPins as binders
Streamlined SPRi-MS coupling to detect and identify a kinase in Cell lysate using the DARPins as binders
DARPins (Designed Ankyrin Repeat Proteins) are a class of non-immunoglobulin binders. Thanks to their specificity and robustness, they allow a multitude of novel, so far unfeasible applications. Surface Plasmon Resonance imaging (SPRi) is a powerful label-free technique that enables real-time target detection. Combining SPRi to massspectrometry (MS) allows biomolecules identification using their unique peptide mass fingerprint. In the past this combination was cumbersome and time-consuming. This application note shows how a protein kinase (RPS6KA2), a potential drug target is detected and identified using a hyphenated On-Chip SPR-MS coupling protocol, leading to saving time and money.
Validation of the activity of G-protein-coupled receptors (GPCRs) using SPRi
Validation of the activity of G-protein-coupled receptors (GPCRs) using SPRi
Real time detection of lymphocytes with SPRi
Real time detection of lymphocytes with SPRi
SPRi Imaging of oligosaccharides proteins interactions
SPRi Imaging of oligosaccharides proteins interactions
Protein-Peptide interactions studies with SPRi
Protein-Peptide interactions studies with SPRi
Description of the advantages of combining the use of peptide chips with direct label-free detection as achieved by SPR imaging (SPRi).
Monitoring of interactions between aptamers and human IgE by SPRi
Monitoring of interactions between aptamers and human IgE by SPRi
Monitoring of interactions between aptamers and human IgE by Surface Plasmon Resonance imaging
Monitoring of interactions between aptamers and human IgE by Surface Plasmon Resonance imaging
Interaction between immobilized peptides and protein from sera on Cystamine / Glutaraldehyde functionalized biochip
Interaction between immobilized peptides and protein from sera on Cystamine / Glutaraldehyde functionalized biochip
Detection of birch pollen allergen in the air
Detection of birch pollen allergen in the air
Antibody-Antigen Specific interaction
Antibody-Antigen Specific interaction

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