Particle Characterization
Greetings from your friends at HORIBA Instruments!
We hope you had the opportunity to enjoy a summer vacation. We took a little break from the newsletter last month, but we're back and ready to go with some exciting new seminars, webinars, and notes.
Our latest edition welcomes you to attend our Formulation and Characterization seminars in King of Prussia, PA and Gaithersburg, MD, attend a Webinar on particle characterization techniques in the pharmaceutical industry, visit our new web page on sugar spheres used in the pharmaceutical industry, download a new application note on measuring ink pigments using laser diffraction, and, finally, download a new technical note on setting particle size specifications.
Formulation and Characterization Seminars
Particle Sciences, Integrated BioTherapeutics, MedImmune, Microfluidics and HORIBA Instruments present two 1-day seminars on the use of particle analysis to characterize pharmaceutical materials in King of Prussia, PA on 10/6/09 and Gaithersburg, MD on 10/7/09. The capabilities of modern analytical tools to go beyond simple measurements and provide detailed information about the manufacturing process will be the theme. The agenda is shown below:
- Use of Particle Size Analysis to Characterize Bed Stability over Multiple Cycles in a Packed Chromatography Column
Brad Matanin, MedImmune - Particle Size Determination of a Semi-solid Vaginal Dosage Form
Robert W. Lee, Ph.D., Particle Sciences - A Method for Decreasing Size Variability of Virus-Like Particle (VLP) Vaccine Preparations
Robert Unfer, Ph.D., Integrated BioTherapeutics - Particle Characterization Applications in the Pharmaceutical Industry
Mark Bumiller, HORIBA Instruments - Microfluidizer High Shear Fluid Processing and Applications Nanoemulsions and Nanosuspensions; Nanoencapsulation and Crystallization
Thomai "Mimi" Panagiotou, Ph.D., Microfluidics - Nanoparticles, Nanotechnology and Nano-nonsense
Mark Bumiller, HORIBA Instruments, Inc.
Please click here to register for the seminars.
Please click here for more information about the speakers and their topics.
Webinar on Particle Characterization in the Pharmaceutical Industry
Please join us for a web-based seminar (or Webinar) Monday, October 5th at 1:30 PM Eastern (10:30 AM Pacific) on particle characterization techniques, applications, and regulatory issues in the pharmaceutical industry. Topics covered include:
- Why particle size is important
- USP and FDA considerations
- Modern techniques for particle size, shape, and zeta potential
- Applications including solid dosage forms, aerosols and nanoparticles
As always, attending the Webinar is easy and free of charge. We will be glad to help you understand how to attend.
Particle Size Analysis of Inks
Ink is a complex medium composed of solvents, pigments, dyes, resins, lubricants, solubilizers, surfactants, particulate matter, fluorescers, and other materials. Particle size of the pigment particles can significantly affect the color strength, surface finish, and durability of the final product. Both DLS and laser diffraction are acceptable techniques for measuring the particle size of ink pigments in the 50 - 200 nm size range. This application note investigates and proves the capability of laser diffraction to effectively measure ink pigment particles in this size range.
Application Note AN183 on Particle Size Analysis of Ink (You need to be logged in).
Setting Particle Size Specifications
The creation of a meaningful and product-appropriate particle size specification requires knowledge of its effect on product performance in addition to an understanding of how results should be interpreted for a given technique. This technical note provides guidelines for setting particle size specifications on particulate materials - primarily when using the laser diffraction technique, but also with information about dynamic light scattering (DLS), acoustic spectroscopy, and image analysis.
Technical Note TN161 Setting Particle Size Specifications (You need to be logged in).
Sugar Spheres Used in the Pharmaceutical Industry
Many solid oral dosage forms are based upon coating sugar spheres with layers of active ingredient, binders, and coatings. These engineered granules are then either mixed with other excipients and compressed into tablets or loaded into a capsule.
The size and shape of the beginning cores (also called nonpareil beads) should be monitored to ensure acceptable product quality. If the core is under- or over-sized and misshapen, then coating deposition will be effected - potentially harming performance characteristics. In addition to providing initial and final quality control, the CAMSIZER dynamic image analyzer can monitor coating layer thicknesses, amount of broken particles/beads, and several other metrics useful in investigation. Papers published in the scientific literature have discussed how the CAMSIZER has been used to replace sieves and hand-counting to quantify the size and shape of sugar spheres used in the pharmaceutical industry.
Upcoming Customer Training Courses
The HORIBA Particle Characterization Group has been steadily expanding our offering of customer training courses. The next laser diffraction (LA-series instruments) training courses will be held in beautiful, sunny Irvine, California, October 13-14.
Click for information on "Boot Camp" customer training course registration.
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