|   Press Release

More powerful nanoparticle analysis with Raman spectroscopy, hyperspectral imaging and enhanced darkfield illumination on the same microscope platform.

Piscataway, NJ and Auburn, AL  – June 10th, 2020  HORIBA Scientific, global leader in measurement and analysis solutions for research and industry, and world leader in Raman spectroscopy, announces combined products using leading technology from CytoViva, Inc. By combining HORIBA’s Raman microscopes with CytoViva’s Hyperspectral Imaging (HSI) microscopy module and Enhanced Darkfield (EDF) illumination, Raman analysis is faster and more powerful.

This innovative integration is of major interest for applications related to nanomaterials research, drug delivery, nanotoxicology studies and SERS nanoparticles characterization. Hyperspectral imaging microscopy allows rapid imaging across the sample with high sensitivity. Colored images generated from the spectra guide the user to easily locate nanoparticles and features of interest.

The patented CytoViva enhanced darkfield illumination improves the signal-to-noise ratio up to ten times over standard darkfield microscopes. The detection limit in size improves sufficiently to allow visualizing nanoparticles as small as 10 nm when isolated.

Raman spectroscopy is a powerful technology for research and industry and provides detailed information on sample properties such as chemical structure, phase, polymorphism, intrinsic material stress, contamination and impurities.

Integrating Raman with hyperspectral imaging and enhanced darkfield allows users to rapidly visualize the sample and target regions of interest. They can then leverage Raman measurements from the identical field of view to provide and confirm the chemical identify of nanoparticles or other sample elements.

“CytoViva’s innovative enhanced darkfield illumination and hyperspectral imaging are perfectly complemented by HORIBA’s world-leading Raman instrumentation,” said Dr. Andrew Whitley, Vice President and Global Director of Business Development for HORIBA Scientific. “Benefits of combined technologies far exceed the sum of their parts”; in this case the chemical specificity afforded by Raman can be quickly targeted to individual nanoparticles which the CytoViva components localize within minutes or even seconds.”

In this application example, gold nanoparticles are imaged in tissue (top), with the corresponding optical (bottom left) and Raman (bottom right) spectra showing clear differences between the nanoparticles and tissue. Visualization of the nanoparticles is made simple with the hyperspectral imaging, while Raman provides a detailed chemical fingerprint.

The combined offerings are available from HORIBA now for new system sales and for upgrades to existing Raman systems by HORIBA and microscope systems by CytoViva.  More information can be found at: https://www.horiba.com/en_en/raman-cytoviva/

About HORIBA Scientific

HORIBA Scientific, part of HORIBA Instruments Incorporated, headquartered in the United States, provides an extensive array of instruments and solutions for applications across a broad range of scientific R&D and QC measurements. HORIBA Scientific is a world leader in OEM Spectroscopy, elemental analysis, fluorescence (including the PTI brand), forensics, GDS, ICP, particle characterization, Raman, spectroscopic ellipsometry, sulfur-in-oil, SPRi and water quality measurements, as well as XRF.

Our instruments are found in universities and industries around the world. Proven quality and trusted performance have established widespread confidence in the HORIBA Brand.

HORIBA supplies over 500 types of scientific analyzers to universities, research institutions, various manufacturing industries and the government. In some of the most advanced science and technologies, HORIBA provides multi-faceted data solutions for what are niche markets – assisting the most cutting-edge research in the tackling of uncharted territories.

Building on a long tradition of pursuing innovative technology to advance scientific efforts, HORIBA Instruments Incorporated has acquired and assimilated renowned companies such as Société Générale d’Optique (1969), SPEX (1988), Dilor (1995), SOFIE (1996), Jobin Yvon (1997), IBH (2003), GenOptics (2009), and Photon Technology International (2014).

The HORIBA Group is a global company that offers solutions and engineering services, based on our strong performance in developing and manufacturing instruments and products in the analysis and measurement fields. With “Explore the Future” as its brand message, HORIBA has been pursuing state-of-the-art analysis and measurement technology since its establishment in 1945. Founded in the historic city of Kyoto, Japan, it has grown steadily throughout its 75 years of business and is now providing services worldwide as the leader in the analysis technology field. 

We engage in five different business segments with high value-added products and services: Automotive Test Systems, Medical-Diagnostic Instruments and Systems, Semiconductor Instruments and Systems, Scientific Instruments and Systems, and Process and Environmental Instruments and Systems. We have established an optimal number of business bases in Japan, Asia, Europe, and the Americas.

About CytoViva

CytoViva® is the premier provider of integrated, optical microscopy and hyperspectral imaging technologies, with installations at hundreds of leading research institutions around the world. Based on patented enhanced darkfield microscopy optics developed at Auburn University, the CytoViva product line was specifically designed to support research initiatives in nanotechnology. CytoViva’s integrated hyperspectral imaging capability enables high resolution optical spectral characterization and spectral mapping of nanoscale sample elements in both biological and materials-based environments.  CytoViva was founded in 2003 and is headquartered in the Auburn Research Park in Auburn, AL, USA.

Media Contacts

Joanne Lowy
Marketing Supervisor HORIBA Scientific
HORIBA Instruments, Incorporated
20 Knightsbridge Road,
Piscataway, NJ  08854
732‐494‐8660 ext. 8142 / Direct Line: 732‐623‐8142

Stewart Mills
Marketing and Sales Support Manager, CytoViva, Inc.
570 Devall Drive Suite 301 Auburn, AL 36832

In this application example, gold nanoparticles are imaged in tissue (top), with the corresponding optical (bottom left) and Raman (bottom right) spectra showing clear differences between the nanoparticles and tissue.